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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: To determine the associations between serum osteocalcin level and insulin resistance, coronary atherosclerosis by using dual-source coronary computed tomography angiography. Methods: A total of 98 subjects (24 men and 74 women) were selected for this retrospective cross-sectional study who voluntarily visited a health examination center for routine health check-up including the blood test for serum osteocalcin level and coronary computed tomography angiography. Multiple regression analysis was used to determine which variables were independently related to osteocalcin levels and coronary atherosclerosis. Results: Stepwise multiple regression analysis adjusted for age, sex, menopausal status, body mass index, serum alkaline phosphatase, serum calcium and phosphate showed that osteocalcin negatively correlated with serum glucose (β=-0.145, P=0.001) and homeostasis model assessment of insulin resistance (HOMA-IR) index (β=-1.794, P=0.027) independently. The age, serum glucose, smoking status but not osteocalcin level were independent risk factors for coronary atherosclerosis by use of multiple logistic regression analysis after controlling for other variables. Conclusions: Serum osteocalcin level was inversely associated with fasting glucose level and insulin resistance measured by HOMA-IR, suggesting that osteocalcin is important for glucose metabolism. However, in this study, no significant difference was observed in the serum osteocalcin level according to the presence of coronary atherosclerotic plaques.
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참고문헌 (30)
참고문헌 신청
Kanazawa I / 2015 / Osteocalcin as a hormone regulating glucose metabolism / World J Diabetes 6:1345~1354
Lee NK / 2007 / Endocrine regulation of energy metabolism by the skeleton / Cell 130:456~469
Ferron M / 2008 / Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice / Proc Natl Acad Sci U S A 105:5266~5270
Kindblom JM / 2009 / Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men / J Bone Miner Res 24:785~791
Fernández-Real JM / 2009 / The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training / J Clin Endocrinol Metab 94:237~245
Lee NK / 2007 / Endocrine regulation of energy metabolism by the skeleton / Cell 130:456~469
Ferron M / 2008 / Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice / Proc Natl Acad Sci U S A 105:5266~5270
Kindblom JM / 2009 / Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men / J Bone Miner Res 24:785~791
Fernández-Real JM / 2009 / The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training / J Clin Endocrinol Metab 94:237~245
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