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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 125 - 129 (5page)
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초록· 키워드
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Osteocalcin is the most abundant non-collagenous protein produced in bone. It has traditionally been regarded as a marker of bone turnover and is thought to act in the bone matrix to regulate mineralization. However, emerging knowledge regarding osteocalcin has expanded to include functions in energy metabolism, fertilization, and regulation of cognition. Fully carboxylated osteocalcin binds to hydroxyapatite, thereby modulating bone turnover, whereas undercarboxylated osteocalcin in the circulation binds to osteocalcin-sensing receptors and acts as a hormone that affects multiple physiological aspects. In this review, we summarize the current knowledge regarding the hormonal actions of osteocalcin in various organs and potential cellular downstream signaling pathway that may be involved.
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참고문헌 (44)
참고문헌 신청
Jianwen Wei / 2015 / An overview of the metabolic functions of osteocalcin / Reviews in Endocrine and Metabolic Disorders 16(2):93~98
Gérard Karsenty / 2012 / The contribution of bone to whole-organism physiology / Nature 481(7381):314~320
Na Kyung Lee / 2007 / Endocrine Regulation of Energy Metabolism by the Skeleton / Cell 130(3):456~469
Thomas L Clemens / 2011 / The osteoblast: An insulin target cell controlling glucose homeostasis / Journal of Bone and Mineral Research 26(4):677~680
Peter V. Hauschka / 1989 / Osteocalcin-hydroxyapatite interaction in the extracellular organic matrix of bone / The Anatomical Record 224(2):180~188
Gérard Karsenty / 2012 / The contribution of bone to whole-organism physiology / Nature 481(7381):314~320
Na Kyung Lee / 2007 / Endocrine Regulation of Energy Metabolism by the Skeleton / Cell 130(3):456~469
Thomas L Clemens / 2011 / The osteoblast: An insulin target cell controlling glucose homeostasis / Journal of Bone and Mineral Research 26(4):677~680
Peter V. Hauschka / 1989 / Osteocalcin-hydroxyapatite interaction in the extracellular organic matrix of bone / The Anatomical Record 224(2):180~188
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