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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Recently, a Korean fracture-risk assessment tool (FRAX) model has become available, but large prospective cohort studies, which are needed to validate the model, are still lacking, and there has been little effort to evaluate its usefulness. This study evaluated the clinical usefulness of the FRAX model, a FRAX developed by the World Health Organization, in Korea. Methods: In 405 postmenopausal women and 139 men with a proximal femoral fracture, 10-year predicted fracture probabilities calculated by the Korean FRAX model (a country-specific model) were compared with the probabilities calculated with a FRAX model for Japan, which has a similar ethnic background (surrogate model). Results: The 10-year probabilities of major osteoporotic and hip fractures calculated by the Korean model were significantly lower than those calculated by the Japanese model in women and men. The fracture probabilities calculated by each model increased significantly with age in both sexes. In patients aged 70 or older, however, there was a significant difference between the two models. In addition, the Korean model led to lower probabilities for major osteoporotic fracture and hip fracture in women when BMD was excluded from the model than when it was included. Conclusions: The 10-year fracture probabilities calculated with FRAX models might differ between country-specific and surrogate models, and caution is needed when applying a surrogate model to a new population. A large prospective study is warranted to validate the country-specific Korean model in the general population.
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참고문헌 (27)
참고문헌 신청
Braithwaite RS / 2003 / Estimating hip fracture morbidity, mortality and costs / J Am Geriatr Soc 51 : 364 ~ 370
Choi YJ / 2012 / The prevalence of osteoporosis in Korean adults aged 50 years or older and the higher diagnosis rates in women who were beneficiaries of a national screenin
Ensrud KE / 2009 / A comparison of prediction models for fractures in older women: is more better? / Arch Intern Med 169 : 2087 ~ 2094
Ettinger B / 2013 / Performance of FRAX in a cohort of community
Fujiwara S / 2008 / Development and application of a Japanese model of the WHO fracture risk assessment tool(FRAX) / Osteoporos Int 19 : 429 ~ 435
Choi YJ / 2012 / The prevalence of osteoporosis in Korean adults aged 50 years or older and the higher diagnosis rates in women who were beneficiaries of a national screenin
Ensrud KE / 2009 / A comparison of prediction models for fractures in older women: is more better? / Arch Intern Med 169 : 2087 ~ 2094
Ettinger B / 2013 / Performance of FRAX in a cohort of community
Fujiwara S / 2008 / Development and application of a Japanese model of the WHO fracture risk assessment tool(FRAX) / Osteoporos Int 19 : 429 ~ 435
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