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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 14 (14page)
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Background: Aromatase inhibitors (AIs) play an important role in the endocrine therapy of postmenopausal breast cancer patients, with a recent tendency to extend the duration of their use. However, AIs may increase the risk of osteoporotic bone fractures. This meta-analysis evaluated the risk of osteoporotic fractures of the hip, spine, and other locations in breast cancer patients using AIs. Methods: We performed a systematic search to identify randomized controlled clinical trials that investigated osteoporotic fractures in breast cancer patients on AI therapy. The main outcomes were the incidence and risk of osteoporotic fractures in general and of hip, vertebral, and non-vertebral fractures in AI users and controls. Results: The systematic review found a total of 30 randomized controlled trials including 117,974 participants. The meta-analysis showed a higher incidence of osteoporotic fracture in AI users: The crude risk ratio for all osteoporotic fractures was 1.35 (95% confidence interval [CI], 1.29–1.42; P < 0.001), for hip fractures 1.18 (95% CI, 1.02–1.35; P < 0.001), for vertebral fractures 1.84 (95% CI, 1.36–2.49; P < 0.001), and for non-vertebral fractures 1.18 (95% CI, 1.02–1.35; P < 0.001), respectively, compared to the controls. Conclusion: Our meta-analysis suggested an increased risk of osteoporotic fractures for AI therapy in patients with breast cancer that was most expressed for vertebral fractures. Breast cancer patients on AIs need to be monitored for osteoporosis and osteoporotic fractures, and active prevention measures should be implemented.
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참고문헌 (61)
참고문헌 신청
Yap YS / 2019 / Insights into breast cancer in the East vs the West:a review / JAMA Oncol
Howlader N / 2014 / US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status / J Natl Cancer Inst 106(5):dju055
Dowsett M / 2010 / Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen / J Clin Oncol 28(3):509~518
Mauri D / 2006 / Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer : meta-analysis / J Natl Cancer Inst 98(18):1285~1291
Early Breast Cancer Trialists' Collaborative Group(EBCTCG) / 2015 / Aromatase inhibitors versus tamoxifen in early breast cancer : patient-level meta-analysis of the randomised trials / Lancet 386(10001):1341~1352
Howlader N / 2014 / US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status / J Natl Cancer Inst 106(5):dju055
Dowsett M / 2010 / Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen / J Clin Oncol 28(3):509~518
Mauri D / 2006 / Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer : meta-analysis / J Natl Cancer Inst 98(18):1285~1291
Early Breast Cancer Trialists' Collaborative Group(EBCTCG) / 2015 / Aromatase inhibitors versus tamoxifen in early breast cancer : patient-level meta-analysis of the randomised trials / Lancet 386(10001):1341~1352
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