지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 79 - 84 (6page)
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초록· 키워드
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Purpose: Although papillary thyroid microcarcinoma (PTMC) has very excellent prognosis, lymph node metastases are found frequently. This study identifies the risk factors of clinically negative cervical lymph node metastasis (cN0) and investigates the need for central lymph node dissection in cN0 PTMC.Methods: From Jan. 1st 2007 to Dec. 30th 2013, 1593 patients received surgery for papillary thyroid carcinoma. Seven hundred and eleven patients were diagnosed with cN0 PTMCs. They all received thyroidectomy (total thyroidectomy or lobectomy) with prophylactic central neck dissection. We reviewed the medical records and analyzed the risk factors affecting central lymph node metastasis (CLNM).Results: Of 711 PTMCs patients without clinical lymph node metastasis, 170 (23.9%) patients had CLNM. CLNM was frequent in males than females (P＜0.001). The larger the primary tumor, the higher the risk of CLNM (P＜0.001). Extra-thyroidal extension was an independent risk factor of CLNM (P＜0.001). Recurrence rates in the CLNM negative group was 1.3%, and in the CLNM positive group 2.4%. The CLNM positive group recurred at a slightly higher rate, but not statistically significantly (P=0.329). Five year disease free survival in the CLNM negative was 96.8%, and in the positive group 94.1%, not a statistically significant (P=0.630).Conclusion: In this study, male gender, the size of primary tumor, and extra-thyroidal extension were the risk factors of occult LNM but occult LNM in PTMC was not associated with recurrence rate or five-year disease free survivals. Therefore, we can omit prophylactic central lymph node dissection in patient with cN0 PTMC.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Hedinger C / 1989 / The WHO histological classification of thyroid tumors: a commentary on the second edition / Cancer 63:908~911
Davies L / 2006 / Increasing incidence of thyroid cancer in the United States, 1973-2002 / JAMA 295:2164~2167
Ito Y / 2007 / A therapeutic strategy for incidentally detected papillary microcarcinoma of the thyroid / Nat Clin Pract Endocrinol Metab 3:240~248
Mazzaferri EL / 1994 / Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer / Am J Med 97:418~428
Harach HR / 1984 / Occult papillary carcinoma of the thyroid appearing as lung metastasis / Arch Pathol Lab Med 108:529~530
Davies L / 2006 / Increasing incidence of thyroid cancer in the United States, 1973-2002 / JAMA 295:2164~2167
Ito Y / 2007 / A therapeutic strategy for incidentally detected papillary microcarcinoma of the thyroid / Nat Clin Pract Endocrinol Metab 3:240~248
Mazzaferri EL / 1994 / Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer / Am J Med 97:418~428
Harach HR / 1984 / Occult papillary carcinoma of the thyroid appearing as lung metastasis / Arch Pathol Lab Med 108:529~530
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