지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background : Antibiotic resistance has become a serious threat to manage community-acquired pneumonia (CAP). Despite the rapid emergence of drug-resistant organisms, there are no updated guidelines for the initial antibiotic management of CAP. This study was conducted to investigate the resistance of isolated pathogens to empirical antibiotics consistent with recommendations from the 2009 guidelines on the management of CAP.
Methods : A retrospective clinical analysis was conducted, using electronic medical records of the CAP patients, between January 2014 and December 2015, at three teaching hospitals in Korea. The patterns of prescribing empirical antibiotics and the resistance of isolated pathogens to antibiotics were analyzed.
Results : A total of 168 patients were analyzed. The most common pathogen was Acinetobacter baumannii (15.5%), followed by Streptococcus pneumoniae (15.5%), Klebsiella pneumoniae (13.1%), Pseudomonas aeruginosa (13.1%), Staphylococcus aureus (11.9%), and Haemophilus influenza (4.8%). A. baumannii exhibited high resistance rates (81-92%) to ciprofloxacin, levofloxacin, meropenem, and piperacillin/tazobactam, while H. influenzae showed high rates (100%) of sensitivity to the drugs. S. pneumoniae had a high level of resistance (91.3%) to azithromycin and a low resistance rate (11.5%) to ceftriaxone. K. pneumoniae and P. aeruginosa showed a high level of sensitivity to ciprofloxacin (90.9% vs. 86.4%) and piperacillin/tazobactam (90% vs. 88.9%). The resistance rate of S. aureus to ciprofloxacin was 65%, while the sensitivity rate of S. pneumoniae to levofloxacin was 96.2%.
Conclusion : For the initial antibiotic management of CAP due to A. baumannii, the empirical use of ciprofloxacin, levofloxacin, meropenem, or piperacillin/tazobactam is not recommended. Moreover, azithromycin is inappropriate for empirical antibiotics to treat CAP, due to S. pneumoniae. Routine use of ciprofloxacin for empiric treatment of CAP due to S. aureus should also be avoided.
목차
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참고문헌 (16)
참고문헌 신청
American Thoracic Society / 2005 / Guidelines for the management of adults with hospitalacquired, ventilator-associated, and healthcare-associated pneumonia / Am J Respir Cr
Ayukekbong JA / 2017 / The threat of antimicrobial resistance in developing countries : causes and control strategies / Antimicrob Resist Infect Control 6 : 47 ~
KOSIS / / Report on the cause of death statistics
Kalil AC / 2016 / Management of Adults With Hospitalacquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of Ame
Shin JH / 2007 / Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five
Ayukekbong JA / 2017 / The threat of antimicrobial resistance in developing countries : causes and control strategies / Antimicrob Resist Infect Control 6 : 47 ~
KOSIS / / Report on the cause of death statistics
Kalil AC / 2016 / Management of Adults With Hospitalacquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of Ame
Shin JH / 2007 / Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five
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