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논문 기본 정보

자료유형
학술저널
저자정보
Geunhyeok Yang (Kyung Hee University School of Medicine) Chang Woo Kim (Kyung Hee University School of Medicine) Suk-Hwan Lee (Kyung Hee University School of Medicine)
저널정보
대한종양외과학회 KOREAN JOURNAL OF CLINICAL ONCOLOGY Korean Journal of Clinical Oncology 제15권 제2호
발행연도
2019.12
수록면
79 - 85 (7page)

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Purpose: Anastomotic leakage (AL) is a type of intra-abdominal infection (IAI) which requires appropriate antibiotics with proper intervention. This study aimed to improve the appropriateness of antibiotic treatment by assessing the patterns of antibiotic treatment and resistance of pathogen profiles in patients who had AL after colorectal cancer surgery.
Methods: From June 2006 through December 2017, the medical records of the patients who had AL after elective abdominal surgery for colorectal cancer in Kyung Hee University Hospital at Gangdong, Seoul, Korea were reviewed retrospectively. Baseline characteristics and consistence of antibiotics with culture study results were analyzed to evaluate the appropriateness of treatment.
Results: Among 982 patients who underwent primary surgery for colorectal cancer, 41 (4.2%) had AL. Mean time of diagnosis of AL from surgery was 6.3 days. The most commonly used prophylactic antibiotics for the primary surgery was 2nd generation cephalosporin (66.6%). Mean duration of prophylactic antibiotics usage was 2.8 days. The most commonly used empirical antibiotics after AL occurred was piperacillin and tazobactam (32.6%). Mean duration of empirical antibiotics usage was 8.2 days. The most commonly identified pathogens were Escherichia coli and Enterococci spp. (26.8% each), and 12.2% of the “ESKAPE” pathogens were identified. Resistance to empirical antibiotics was 45.5% (10/22).
Conclusion: Penetration of culture study for AL after colorectal cancer surgery appeared relatively low, although the profile of pathogens isolated from the AL patients can give important clues and evidence for appropriate antibiotics use. Surgeons should pay attention in performing culture studies for IAI including AL for proper patient treatment.
#Intraabdominal infection #Antibiotics #Resistance #Colonic neoplasms #Anastomotic leakage

목차

INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES

참고문헌 (22)

참고문헌 신청
Menichetti F / 2009 / Definition and classification of intra-abdominal infections / J Chemother 21(Suppl 1):3~4 google schola Ventola CL / 2015 / The antibiotic resistance crisis: part 1: causes and threats / P T 40:277~283 google schola Ventola CL / 2015 / The antibiotic resistance crisis: part 2: management strategies and new agents / P T 40:344~352 google schola Sturkenboom MC / 2005 / Inappropriate initial treatment of secondary intra-abdominal infections leads to increased risk of clinical failure and costs / Br J Clin Pharmacol 60:438~443 google schola Solomon SL / 2014 / Antibiotic resistance threats in the United States: stepping back from the brink / Am Fam Physician 89:938~941 google schola

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