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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국피부과학연구원 아시안뷰티화장품학술지 아시안뷰티화장품학술지 제5권 제2호
발행연도
2007.1
수록면
115 - 128 (14page)

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Emulsion that contains a multilayer structure has a similar structure with the multilayer structure existing in the stratum corneum. Emulsion is highly effective for caring a sensitive skin and atopic dermatitis, which a dry skin caused by the damaged stratum corneum of a skin and a reduction of the content of ceramide in a living body, are known as the causes for. However, it is difficult to make an end product of emulsion have the structure stably because stability becomes different, depending on the ratio among ceramide, fatty acid (intercellularlipid), and cholesterol, on the mixture ratio of oily components, on the mixture ratio of emulsifiers, and the mixture ratio of polyhydric alcohol. In this study, a multilayer structure was made by differentiating emulsifiers only without any changes in the kinds and the ratio of other components. By doing this, an emulsifier, which makes it easy to create lamellar liquid crystal, was developed, through which a more stable multilayer structure could be made. Used emulsifiers are C14-22Alcohol & C12-20Alkyl Glucoside, Lechthin & C12-16Alcohol & Palmitic Acid, Hydrgenated Lecithin & C12-16Alcohol & Palmitic Acid, Myristyl alcohol & Hydrogenated Lecithin & Palmitic acid & Cetearyl Alcohol & Lecithin & Glyceryl Stearate, Batyl Alcohol & Stearic acid & Lecithin, Sorbitan Stearate & Sucrose Cocoate, Stearath 21, Stearath 2, Cetearyl Glucoside & Cetearyl Alcohol and Cetearyl Olivate & Sorbitan Olivate. As another experiment, this paper selected myristyl alcohol, hydrogenated lecithin, palmitic acid, cetearyl alcohol, lecithin, and glyceryl stearate, which have the best optical aeolotropy, out of the emulsifier made in the first experiment. And then, it made ceramide-3 of the same type as found in the human bodies by purifying yeast. Using the components selected from the emulsifier and the ceramide-3, it made another emulsifier and observed its aeolotropy through an optical microscope. The emulsifier containing ceramide was found to have a greater number of clearer maltese cross of a fixed size than the ceramide-free emulsifier. Thispaper kept the emulsifier containing ceramide, myristyl alcohol, hydrogenated lecithin, palmitic acid, cetearyl alcohol, lecithin and glyceryl stearate in a cycling incubator at -20℃〫～45℃(cooling and heating or freezing and thawing conditions are available) for 6 weeks and had a stability test. No difference in the optical aeolotropy was found before and after that. In order to measure the effect of moisturizing the skins and Transepidermal Water Loss(TEWL), this paper applied Liquid A (containing ceramide, myristyl alcohol, hydrogenated lecithin, palmitic acid, cetearyl alcohol, lecithin, glyceryl stearate), Liquid B of a gel type (the control group of Liquid A), and Liquid C of a traditional O/W type, about 2mg/cm² each, on the right and the left. And then, it made non-treatment control measurement on the outside of the applied part. It let the subject apply them twice a day, in the morning and in the evening. The measurement was made on the 3rd, the 7th, and the 14th day of the experiment. As a result, the emulsifier of the multilayer structure containing ceramide showed the best skin-moisturizing effect and evaporation-suppressing effect.of this study is to examine.
#Emulsifier #mixture ratio #lamellar liquid crystal #aeolotrpy #evaporation

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