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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 100 - 106 (7page)
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Alcohol influences the neuroadaptation of brain cells where receptors and enzymes like protein kinase C (PKC) exist. Naltrexone acts on opioid receptors. However, other mechanisms of action remain unknown. We prepared SH-SY5Y neuroblastoma cells, and fed them with 150 mM ethanol for 72 h followed by treatment with naltrexone for 24 h. We performed microarray analysis and reversetrans-criptase-polymerase chain reaction. Our results showed that PKCε increased 1.90 times and showed an overall decreasing pattern as time increased. Phosphorylated ERK also increased 2.0 times according to the change of PKCε. Integrin α7 increased 2.32 times and showed an increasing pattern as time increased. In conclusion, naltrexone influences PKCε neuronal signaling system and endothelial adhesion molecule integrin α7 in addition to the well-known opioid system.
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참고문헌 (21)
참고문헌 신청
/ / Characterization of the -opioid receptor found in SH-SY5Y neuroblastoma cells
/ 1998 / Neuronal signaling systems and ethanol dependence. 17 : 1 ~ 15
/ 2000 / Genetic factors in addiction OTL map-ping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice 96 : 139 ~ 49
/ 2000 / Reduced operant ethanol self-administration and in vivo mesolimbic dopamine responses to ethanol in PKC-deficient mice 12 : 4131 ~ 40
/ 2001 / Quantification of HER2/neu gene amplification by com-petitive PCR using fluorescent melting curve analysis 47 : 844 ~ 51
/ 1998 / Neuronal signaling systems and ethanol dependence. 17 : 1 ~ 15
/ 2000 / Genetic factors in addiction OTL map-ping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice 96 : 139 ~ 49
/ 2000 / Reduced operant ethanol self-administration and in vivo mesolimbic dopamine responses to ethanol in PKC-deficient mice 12 : 4131 ~ 40
/ 2001 / Quantification of HER2/neu gene amplification by com-petitive PCR using fluorescent melting curve analysis 47 : 844 ~ 51
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