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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 103 - 109 (7page)
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초록· 키워드
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Oxidative stress has been implicated in mediation of vascular disorders. In the presence of vanadate, H2O2 induced tyrosine phosphorylation of PLD1, protein kinase C-α (PKC-α), and other unidentified proteins in rat vascular smoth muscle cels constitutively associated with PKC-α in VSMCs. Stimulation of the cells by H2O2 and vanadate showed a concentration-dependent tyrosine phos-phorylation of the proteins in PLD1 imunopre-cipitates and activation of PLD. Pretreatment of the cells with the protein tyrosine kinase inhibitor, genistein resulted in a dose-dependent inhibition of H2O2-induced PLD activation. PKC inhibitor and down-regulation of PKC abolished H2O2-stimulated stress (H2O2) caused increased cel migration. This effect was prevented by the pretreatment of cells with tyrosine kinase inhibitors, PKC inhibitors, and 1-butanol, but not 3-butanol. Taken together, these results sugest that PLD might be involved in oxidative stres-induced migration of VSMCs, pos-sibly via tyrosine phosphorylation and PKC acti-vation.
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참고문헌 (31)
참고문헌 신청
/ / A rapid and sensitive method for the quantitationof microgram quantities of protein utilizing the principleof protein-dye binding : 248 ~ 54
/ / Activation of endothelial cellphospholipase D by hydrogen peroxide and fatty acid hydroperoxide : 930 ~ 7
/ / Epidermal growth factor-induced hydrolysis of phosphatidylcholineby phospholipase D and phospholipase C inhuman dermal fibroblasts : 309 ~ 17
/ / Phospholipase D activation by themitogens platelet-derived growth factor and 12-O-tetradecanoylphorbol13-acetate in NIH-3T3 cells : 64 ~ 7
/ / Selective inhibition of protein tyrosinephosphatase activities by H2O2 and vanadate in vitro : 773 ~ 9
/ / Activation of endothelial cellphospholipase D by hydrogen peroxide and fatty acid hydroperoxide : 930 ~ 7
/ / Epidermal growth factor-induced hydrolysis of phosphatidylcholineby phospholipase D and phospholipase C inhuman dermal fibroblasts : 309 ~ 17
/ / Phospholipase D activation by themitogens platelet-derived growth factor and 12-O-tetradecanoylphorbol13-acetate in NIH-3T3 cells : 64 ~ 7
/ / Selective inhibition of protein tyrosinephosphatase activities by H2O2 and vanadate in vitro : 773 ~ 9
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