지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 230 - 240 (11page)
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apoptosis protein (IAP) family, which is known to be over-expressed in various carcinomas and associated with their biologically aggressive characteristics. The aim of this study was to investigate survivin expression in human medullary thyroid carcinoma (MTC) and a MTC cell line TT, correlate suvivin expression with clinicopathologic features of MTC, and test effects of antisurvivin oligonucleotides (ASODNs) on growth and apoptosis of TT cells. Survivin expression was immunohistochemically determined in formalin-fixed and paraffinembedded specimens obtained from 10 cases of normal thyroid (NT) and 10 cases of MTC, and in TT cells. In TT cells, we confirmed survivin expression and its down-regulation by ASODNs using RT-PCR and Western blot analyses, and investigated effects of ASODNs on viability and growth by MTT assay and apoptosis by apoptotic analyses including DNA laddering assay, acridine orange/ethidium bromide staining and flow cytometric cell cycle analysis. Immunohistochemical analysis showed high survivin expression in MTC and TT cells, whereas no immunoreactivity was detectable in NT. Statistical analyses revealed no significant correlation of survivin expression with the clinicopathologic features of MTC. In TT cells, survivin expression at both mRNA and protein levels was confirmed and could be down-regulated by ASODNs concomitant with decrease in viability and growth, and increase in apoptosis. Our results suggest that survivin plays an important role in MTC independent of the conventional clinicopathologic factors, and ASODNs is a promising survivin- targeted gene therapy for MTC.
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참고문헌 (31)
참고문헌 신청
/ 1899-903 / Complete response to combination chemotherapy with da-carbazine and 5-fluorouracil
/ 1996 / Medullary thyroid cancer: analyses of survival and prognostic factors and the role of radiation therapy in local control. 6 : 305 ~ 10
/ 1997 / A novel anti-apoptosis gene , survivin, expressed in cancer and lymphoma. 3 : 917 ~ 21
/ 1998 / Control of apoptosis and mitotic spindle checkpoint by survivin : 580 ~ 4
/ 1998 / Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer 58 : 5071 ~ 4
/ 1996 / Medullary thyroid cancer: analyses of survival and prognostic factors and the role of radiation therapy in local control. 6 : 305 ~ 10
/ 1997 / A novel anti-apoptosis gene , survivin, expressed in cancer and lymphoma. 3 : 917 ~ 21
/ 1998 / Control of apoptosis and mitotic spindle checkpoint by survivin : 580 ~ 4
/ 1998 / Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer 58 : 5071 ~ 4
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