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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 525 - 534 (10page)
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초록· 키워드
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Catechins, components of green tea, reduce the incidence of cardiovascular diseases such as atherosclerosis. Angiotensin II (Ang II) is highly implicated in the prolifmuscle cells (VSMC), resulting in atherosclerosis. The acting mechanisms of the catechins remain to be defined in the proliferation of VSMC induced by Ang II. Here we report that catechin, epicatechin (EC), epicatechingallate (ECG) or epigallocatechingallate (EGCG) significantly inhibits the Ang II-induced [3H]thymidine incorporation into the primary cultured rat aortic VSMC. Ang II increases the phosphorylation of the extracellular signal-regulat-ed protein kinase 1/2 (ERK 1/2), c-jun-N-terminal kinase 1/2 (JNK 1/2), or p38 mitogen-activated protein kinases (MAPKs) and mRNA expression of c-jun and c-fos. The EGCG pretreatment inhibits the Ang
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참고문헌 (28)
참고문헌 신청
/ / Isolation andcharacterization of rat and human glyceraldehyde-3-phosphatedehydrogenase cDNAs Genomic complexity andmolecular evolution of the gene : 2485 ~ 502
/ / Neurohumoralmechanisms in heart failure role in pathogenesis : 3162 ~ 9
/ 1995 / Angiotensin II mediated signal transduction events in vascular smooth muscle cells kinases and phosphatases 2 : 55 ~ 60
/ 1995 / Effects of epigallocatechin3 Ogallate green tea tannin on the life span of stroke prone spontaneously hypertensive rats 22 : 302 ~ 303
/ 1996 / Identification of an essential signaling cascade for mitogen activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells 271 :
/ / Neurohumoralmechanisms in heart failure role in pathogenesis : 3162 ~ 9
/ 1995 / Angiotensin II mediated signal transduction events in vascular smooth muscle cells kinases and phosphatases 2 : 55 ~ 60
/ 1995 / Effects of epigallocatechin3 Ogallate green tea tannin on the life span of stroke prone spontaneously hypertensive rats 22 : 302 ~ 303
/ 1996 / Identification of an essential signaling cascade for mitogen activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells 271 :
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녹차 카테킨, Epigallocathechin Gallate (EGCG)의 흰쥐췌장종양 선 세포 AR42J의 MAP Kinase 세포 신호전달 기전을 통한 Neurogenin 3 발현에 미치는 영향
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