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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 65 - 73 (9page)
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초록· 키워드
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Cardiomyocyte hypertrophy is a major cause of
morbidity and mortality worldwide. The aim of this
study is to determine the effects of sodium tans -
hinone IIA sulfonate (STS) on cardiomyocyte hypertrophy
induced by angiotensin II (Ang II) in vivo
and in vitro. In long-term treatment, adult Wistar rats
were infused with Ang II for three weeks via osmotic
mini-pumps and some of them were given intragas -
trically of STS. Left ventricle was isolated; the ratio
of left ventricular weight to body weight and systolic
blood pressure (SBP) were determined and heart
morphometry was assessed after hematoxylin and
eosin staining. Results indicated STS inhibited Ang
II-induced increases in myocyte diameter and
decreased the LVW/BW ratio independent of decreasing
systolic blood pressure. In vitro, treatment
of cultured cardiomyocytes with STS inhibited Ang
II-induced increase in cell size, protein synthesis,
ANP expression, activation of extracellular signalregulated
kinase (ERK) and ERK kinase (MEK). Then
we reexamined the mechanism of STS-induced antihypertrophic
effects. Results revealed MEK inhibitor
U0126 (20 µM) markedly enhanced STS-induced
depressions in [3H]leucine incorporation and ANP
expression. In conclusion, MEK/ERK pathway plays
a significant role in the anti-hypertrophic effects of
STS.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Baker KM / / Angiotensin II stimulation of protein synthesis and cell growth in chick heart cells : 610 ~ 8
Bueno OF / 2000 / The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice 19 : 6341 ~ 6350
Cohn JN / 2000 / Cardiac remodeling-concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf on an international forum
Dostal DE / 1999 / The cardiac renin-angiotensin system: conceptual, or a regulator of cardiac function? 85 : 643 ~ 650
Favata MF / 1998 / Identification of a novel mitogen inhibitor of mitogen-activated protein kinase kinase 273 : 18623 ~ 18632
Bueno OF / 2000 / The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice 19 : 6341 ~ 6350
Cohn JN / 2000 / Cardiac remodeling-concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf on an international forum
Dostal DE / 1999 / The cardiac renin-angiotensin system: conceptual, or a regulator of cardiac function? 85 : 643 ~ 650
Favata MF / 1998 / Identification of a novel mitogen inhibitor of mitogen-activated protein kinase kinase 273 : 18623 ~ 18632
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