지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 12 (12page)
이용수
이 논문의 연구 히스토리 (2)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Th17 cells promote inflammatory reactions, whereas regulatory T (Treg) cells inhibit them. Thus, the Th17/Treg cell balance is critically important in inflammatory diseases. However, the molecular mechanisms underlying this balance are unclear. Here, we demonstrate that casein kinase 2 (CK2) is a critical determinant of the Th17/Treg cell balance. Both the inhibition of CK2 with a specific pharmacological inhibitor, CX-4945, and its small hairpin RNA (shRNA)-mediated knockdown suppressed Th17 cell differentiation but reciprocally induced Treg cell differentiation in vitro. Moreover, CX-4945 ameliorated the symptoms of experimental autoimmune encephalomyelitis and reduced Th17 cell infiltration into the central nervous system. Mechanistically, CX-4945 inhibited the IL-6/STAT3 and Akt/mTOR signaling pathways. Thus, CK2 has a crucial role in regulating the Th17/Treg balance.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Brunkow ME / 2001 / Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse / Nat Genet 27 : 68 ~ 73
Chen Dong / 2011 / Genetic controls of Th17 cell differentiation and plasticity / Experimental and Molecular Medicine 43 (1) : 1 ~ 6
Chi H / 2012 / Regulation and function of mTOR signalling in T cell fate decisions / Nat Rev Immunol 12 : 325 ~ 338
Cho ML / 2006 / STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient m
Dang EV / 2011 / Control of T(H)17/T(reg)balance by hypoxia-inducible factor 1 / Cell 146 : 772 ~ 784
Chen Dong / 2011 / Genetic controls of Th17 cell differentiation and plasticity / Experimental and Molecular Medicine 43 (1) : 1 ~ 6
Chi H / 2012 / Regulation and function of mTOR signalling in T cell fate decisions / Nat Rev Immunol 12 : 325 ~ 338
Cho ML / 2006 / STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient m
Dang EV / 2011 / Control of T(H)17/T(reg)balance by hypoxia-inducible factor 1 / Cell 146 : 772 ~ 784
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The transcription factor NFIL3 controls regulatory T-cell function and stability
Experimental and Molecular Medicine
2019 .01
-
The transcription factor Batf3 inhibits the differentiation of regulatory T cells in the periphery
Experimental and Molecular Medicine
2017 .01
-
Interleukin-2/antibody complex expanding Foxp3＋ regulatory T cells exacerbates Th2-mediated allergic airway inflammation
BMB Reports
2019 .01
-
New Battery Cell Balancing Technique Using Near-Field Coupling
AFORE
2021 .10
-
Development of culture strategies for stem cell maintenance and differentiation through regulation of cell behaviors
한국생물공학회 학술대회
2016 .04
-
Resolving the Mutually Exclusive Immune Responses of Chitosan with Nanomechanics and Immunological Assays
한국생물공학회 학술대회
2023 .04
-
Human Cell Atlas and cell-type authentication for regenerative medicine
Experimental and Molecular Medicine
2020 .09
-
FGF2-Mediated Insulin-Producing Beta Cells Differentiated from Human Omentum-Derived Stem Cells
한국생물공학회 학술대회
2022 .04
-
다중권선 변압기를 이용한 능동형 셀 밸런싱 회로에서 밸런싱 전류 전달 효율을 높이기 위한 변압기 설계 방안
전력전자학회논문지
2018 .08
-
A Direct Cell-to-Cell Charge Balancing Circuit for the EV Battery Module
전력전자학회 학술대회 논문집
2015 .07
-
빠른 전하 균일화를 위한 새로운 구조의 셀 밸런싱 회로
전력전자학회논문지
2015 .04
-
Resolving the Mutually Exclusive Immune Responses of Chitosan with Nanomechanics and Immunological Assays
한국생물공학회 학술대회
2023 .10
-
Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells
BMB Reports
2016 .01
-
Active Cell Balancing Circuit for Series-connected Battery Cells
ICPE(ISPE)논문집
2015 .06
-
다중권선 변압기를 이용한 능동형 셀 밸런싱 회로의 에너지 전달 효율을 높이기 위한 향상된 스위칭 패턴
전력전자학회논문지
2019 .08
-
A critical role for Th17 cell-derived TGF-β1 in regulating the stability and pathogenicity of autoimmune Th17 cells
Experimental and Molecular Medicine
2021 .05
-
Immune inflammatory modulation as a potential therapeutic strategy of stem cell therapy for ALS and neurodegenerative diseases
BMB Reports
2018 .01
-
Cell-based biosensor: A new tool to characterize stem cell pluripotency and differentiation
한국생물공학회 학술대회
2018 .10
-
Immunomodulation for Tissue Repair and Regeneration
조직공학과 재생의학
2023 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0