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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 357 - 363 (7page)
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CD43 (sialophorin, leukosialin) is a heavily sialylated surface protein expressed on most leukocytes and platelets including T cells. Although CD43 antigen is known to have multiple and complex structure, exact function of CD43 in each cell type is not completely understood. Here we evaluated the role of CD43 in Fas (CD95)-induced cell death in human T lympho-blastoid cell line, Jurkat. Crosslinking CD43 antigen by K06 mAb increased the Fas-mediated Jurkat cell apoptosis and the augmentation was inhibited by treatment with caspase inhibitors. Further, CD43 signaling of Jurkat cells induced Fas oligomerization on the cell surfaces implying that CD43 ligation have effects on early stage of Fas-induced T cell death. These also suggest that CD43 might play an important role in contraction of the immune response by promotion of Fas-induced apoptosis in human T cells.
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참고문헌 (29)
참고문헌 신청
/ / Expression on blood cells of sialophorin the surface glycoprotein that is defective in Wiskott-Aldrich syndrome : 104 ~ 9
/ / Human T-lymphocyte activation is associated with changes in O-glycan bio-synthesis : 15146 ~ 50
/ 1995 / Apoptosis of human hematopoietic progenitor cells induced by crosslinking of surface CD43 the major sialoglycoprotein of leukocytes 86 : 502 ~ 511
/ 1995 / FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis 81 : 505 ~ 512
/ 1995 / The Fas death factor. : 1449 ~ 56
/ / Human T-lymphocyte activation is associated with changes in O-glycan bio-synthesis : 15146 ~ 50
/ 1995 / Apoptosis of human hematopoietic progenitor cells induced by crosslinking of surface CD43 the major sialoglycoprotein of leukocytes 86 : 502 ~ 511
/ 1995 / FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis 81 : 505 ~ 512
/ 1995 / The Fas death factor. : 1449 ~ 56
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