지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 161 - 170 (10page)
이용수
초록· 키워드
오류제보하기
Increasing importance is being given to the stimulation
of Th1 response in cancer immunotherapy because its
presence can shift the direction of adaptive immune responses
toward protective immunity. Based on chemokine
receptor expression, CXCR3+CCR4-CD4+ T
cells as Th1-type cells were investigated its capacity
in monocyte-derived dendritic cell (DC) maturation
and polarization, and induction of antigen specific cytotoxic
T lymphocytes (CTL) in vitro. The levels of IL-4,
IL-5 and IL-10 were decreased to the basal level compared
with high production of IFN-γ, TNF-α, and IL-2 in
CXCR3+CCR4-CD4+ T cells stimulated with anti-CD3
and anti-CD28 antibodies. Co-incubation of activated
CD4+ or CXCR3+CCR4-CD4+ T cells with DC (CD4+/DC
or CXCR3+CD4+/DC, respectively) particularly up-regulated
IL-12 and CD80 expression compared with DC
matured with TNF-α and LPS (mDC). Although there
was no significant difference between the effects of the
CXCR3+CCR4-CD4+ and CD4+ T cells on DC phenotype
expression, CXCR3+CD4+/DC in CTL culture were able
to expand number of CD8+ T cells and increased frequencies
of IFN-γ secreting cells and overall cytolytic
activity against tumor antigen WT-1. These results
demonstrated that the selective addition of CXCR3+
CCR4- CD4+ T cells to CTL cultures could enhance the
induction of CTLs by DC in vitro, and implicated on a
novel strategy for adoptive T cell therapy.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
[
Chattopadhyay S / 2005 / Continuous presence of Th1 conditions is necessary for longer lasting tumor- specific CTL activity in stimulation cultures with PBL / Hum Immunol 66
Cosmi L / 2000 / CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease / Eur J Immunol 30 : 29
Eiz-Vesper B / 2006 / Tetanus toxoid provides efficient T-cell help for the induction of HA-1(H) cytotoxic T cells / Transfusion 46 : 1210 ~ 1220
Frick JS / 2006 / Colitogenic and non-colitogenic commensal bacteria differentially trigger DC maturation and Th cell polarization: An important role for IL-6 / Eur J Immunol
Chattopadhyay S / 2005 / Continuous presence of Th1 conditions is necessary for longer lasting tumor- specific CTL activity in stimulation cultures with PBL / Hum Immunol 66
Cosmi L / 2000 / CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease / Eur J Immunol 30 : 29
Eiz-Vesper B / 2006 / Tetanus toxoid provides efficient T-cell help for the induction of HA-1(H) cytotoxic T cells / Transfusion 46 : 1210 ~ 1220
Frick JS / 2006 / Colitogenic and non-colitogenic commensal bacteria differentially trigger DC maturation and Th cell polarization: An important role for IL-6 / Eur J Immunol
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Activation of B cells using Schneider 2 cells expressing CD40 ligand for the enhancement of antigen presentation in vitro
Experimental and Molecular Medicine
2005 .01
-
Impaired responses of leukemic dendritic cells derived from a human myeloid cell line to LPS stimulation
Experimental and Molecular Medicine
2006 .01
-
Detection of homodimer formation of CD99 throughextracelluar domain using bimolecular fluorescencecomplementation analysis
Experimental and Molecular Medicine
2007 .01
-
Intracellular CD154 Expression Reflects Antigen-specific CD8+ T Cells butShows Less Sensitivity than Intracellular Cytokine and MHC TetramerStaining
Journal of Microbiology and Biotechnology
2007 .01
-
CD43 cross-linking increases the Fas-induced apoptosis through induction of Fas aggregation in Jurkat T-cells
Experimental and Molecular Medicine
2006 .01
-
Enhancement of antitumor effect using dendritic cells activated with natural killer cells in the presence of Toll-like receptor agonist
Experimental and Molecular Medicine
2010 .01
-
Induction of Regulatory Dendritic Cells by Lactobacillus paracasei L9 Prevents Allergic Sensitization to Bovine β-Lactoglobulin in Mice
Journal of Microbiology and Biotechnology
2015 .01
-
Expression of CCR2A, an isoform of MCP-1 receptor, isincreased by MCP-1, CD40 ligand and TGF-β in fibroblast likesynoviocytes of patients with RA
Experimental and Molecular Medicine
2007 .01
-
사람의 결핵균 특이 CD3+CD4-CD8-γδ T림프구 클론의 항원인지 과정에서 CD1의 역할
The Journal of the Korean Society for Microbiology
1993 .12
-
Homology Modeling of Chemokine Receptor CXCR3: A Novel Therapeutic Target against Inflammatory Diseases
조선자연과학논문집
2015 .01
-
Improving vaccines by targeting antigens to dendritic cells
Experimental and Molecular Medicine
2009 .01
-
CD137 induces adhesion and cytokine production in human monocytic THP-1cells
Experimental and Molecular Medicine
2005 .01
-
Sorting CD4⁺ T Cells in Blood by Magnetic Nanoparticles Coated with Anti-CD4 Antibody
한국자기학회 학술연구발표회 논문개요집
2007 .05
-
Activated natural killer cell-mediated immunity is required for the inhibition of tumor metastasis by dendritic cell vaccination
Experimental and Molecular Medicine
2004 .01
-
Expression of dendritic cell markers on cultured neutrophilsand its modulation by anti-apoptotic and pro-apoptoticcompounds
Experimental and Molecular Medicine
2007 .01
-
Cell-Based IL-15:IL-15Rα Secreting Vaccine as an Effective Therapy for CT26 Colon Cancer in Mice
Molecules and Cells
2019 .01
-
Efficient amplification of melanoma-specific CD8+ T cells usingartificial antigen presenting complex
Experimental and Molecular Medicine
2006 .01
-
Proteomic Analysis of Resting and Activated Human CD8+ T Cells
Journal of Microbiology and Biotechnology
2006 .01
-
Analyses of the TCR repertoire of MHC class II-restricted innate CD4+ T cells
Experimental and Molecular Medicine
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0