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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 428 - 434 (7page)
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A terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay was used to determine that apoptosis causes HeLa cell death induced by pseudolaric acid B. The c-Jun N-terminal kinase (JNK) inhibitor SP600125 decreased p53 protein expression during exposure to pseudolaric acid B. SP600125 decreased the phosphorylation of p53 during pseudolaric acid B exposure, indicating that JNK mediates phosphorylation of p53 during the response to pseudolaric acid B. SP600125 reversed pseudolaric acid B-induced down-regulation of phosphorylated extracellular signal-regulated pro-tein kinase (ERK), and protein kinase C (PKC) was activated by pseudolaric acid B, whereas stau-rosporine, calphostin C, and H7 partly blocked this effect. These results indicate that p53 is partially regulated by JNK in pseudolaric acid B-induced HeLa cell death and that PKC participates in pseudolaric acid B-induced HeLa cell death.
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참고문헌 (22)
참고문헌 신청
/ / Parker PJ. Activation of the mitogen-activated protein kinase/extra-cellular signal-regulated kinase pathway by conventional
/ 1995 / Antifungal evaluation of pseudola-ric acid B a major constituent of pseudolarix kaempferi. 58 : 57 ~ 67
/ 1995 / p53 is phos-phorylated in vitro and in vivo by an ultraviolet radiation-in-duced protein kinase characteristic of the c-jun kinase 270 : 5511 ~ 6
/ 1997 / p53, the cellular gatekeeper for growth and division. 88 : 323 ~ 31
/ 1998 / Signal transduction by the c-Jun N-terminal kinase -from inflammation to development. 10 : 205 ~ 9
/ 1995 / Antifungal evaluation of pseudola-ric acid B a major constituent of pseudolarix kaempferi. 58 : 57 ~ 67
/ 1995 / p53 is phos-phorylated in vitro and in vivo by an ultraviolet radiation-in-duced protein kinase characteristic of the c-jun kinase 270 : 5511 ~ 6
/ 1997 / p53, the cellular gatekeeper for growth and division. 88 : 323 ~ 31
/ 1998 / Signal transduction by the c-Jun N-terminal kinase -from inflammation to development. 10 : 205 ~ 9
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