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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 408 - 416 (9page)
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초록· 키워드
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c-Jun N-terminal kinase (JNK) is activated during hepatic reperfusion, and JNK inhibitors are known to protect other major organs from ischemia-reper-fusion (I/R) injury. We attempted to determine the effect of SP600125, a JNK inhibitor, on hepatic I/R injury using a partial ischemia model in mice. Compared to a vehicle-treated group, the SP600125- treated group showed a greater increase in serum ALT levels 24 h after reperfusion with more severe parenchymal destruction and leukocyte infiltration. Similarly, tissue myeloperoxidase and malondial-dehyde levels were higher in the SP600125-treated group, and chemokine expression was also higher in the SP600125-treated group. These data, which are contradictory to previous results, indicate that JNK inhibition by SP600125 may be harmful in hepatic I/R injury. Therefore, care must be taken when inves-tigating the therapeutic use of JNK inhibitors in hepatic I/R injury, especially in the context of the effects of JNK inhibition on inflammatory infiltration.
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참고문헌 (27)
참고문헌 신청
/ / SP600125 in hepatic reperfusion injury 415
/ / The lipid peroxidation product 4-hydrox-ynonenal is formed by--and is able to attract--rat neutrophils in vivo : 365 ~ 73
/ 1996 / Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver 93 : 12908 ~ 13
/ 1997 / Activation of c-Jun N-terminal kinase during is-chemia and reperfusion in mouse liver 420 : 201 ~ 4
/ 1997 / Reperfusion after liver transplantation in rats differ-entially activates the mitogen-activated protein kinases 25 : 1128 ~ 35
/ / The lipid peroxidation product 4-hydrox-ynonenal is formed by--and is able to attract--rat neutrophils in vivo : 365 ~ 73
/ 1996 / Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver 93 : 12908 ~ 13
/ 1997 / Activation of c-Jun N-terminal kinase during is-chemia and reperfusion in mouse liver 420 : 201 ~ 4
/ 1997 / Reperfusion after liver transplantation in rats differ-entially activates the mitogen-activated protein kinases 25 : 1128 ~ 35
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