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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 8 - 13 (6page)
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Human SIRT1 controls various physiological re-sponses including cell fate, stress, and aging, through deacetylation of its specific substrate protein. In processing DNA damage signaling, SIRT1 attenuates a cellular apoptotic response by deace-tylation of p53 tumor suppressor. The present study shows that, upon exposure to radiation, SIRT1 could enhance DNA repair capacity and deacetylation of repair protein Ku70. Ectopically over-expressed SIRT1 resulted in the increase of repair of DNA strand breakages produced by radiation. On the other hand, repression of endogenous SIRT1 expression by SIRT1 siRNA led to the decrease of this repair activity, indicating that SIRT1 can regulate DNA repair capacity of cells with DNA strand breaks. In addition, repair protein Ku70, leading to subsequent deace-tylation. The dominant-negative SIRT1, a cataly-tically inactive form, did not induce deacetylation of Ku70 protein as well as increase of DNA repair capacity. These observations suggest that SIRT1 modulates DNA repair activity, which could be regulated by the acetylation status of repair protein Ku70 following DNA damage.
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참고문헌 (24)
참고문헌 신청
Anderson RM / 2003 / Yeast life-span extension by calorie restriction is independent of NAD fluctuation 302 : 2124 ~ 2126
Brachmann CB / 1995 / The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability 9 : 2888 ~ 2902
Brunet A / 2004 / Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase 303 : 2011 ~ 2015
Chen WY / 2005 / Tumor Suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses 123 : 437 ~ 448
Cohen HY / 2004a / Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis 13 : 627 ~ 638
Brachmann CB / 1995 / The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability 9 : 2888 ~ 2902
Brunet A / 2004 / Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase 303 : 2011 ~ 2015
Chen WY / 2005 / Tumor Suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses 123 : 437 ~ 448
Cohen HY / 2004a / Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis 13 : 627 ~ 638
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