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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 629 - 637 (9page)
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초록· 키워드
오류제보하기
Inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) have been known to be involved in various pathophysiological processes such as inflammation. This study was performed to determine the regulatory function of superoxide dismutase (SOD) on the LPS-induced expression of iNOS, and COX-2 in RAW 264.7 cells. When a cell-permeable SOD, Tat- SOD, was added to the culture medium of RAW 264.7 cells, it rapidly entered the cells in a dose-dependent manner. Treatment of RAW 264.7 cells with Tat-SOD led to decrease in LPS-induced ROS generation. Pretreatment with Tat-SOD significantly inhibited LPS-induced expression of iNOS and NO production but had no effect on the expression of COX-2 and PGE2 production in RAW 264.7 cells. Tat-SOD inhibited LPS-induced NF-κB DNA binding activity, IκBα degradation and activation of MAP kinases. These data suggest that SOD differentially regulate expression of iNOS and COX-2 in LPS-stimulated RAW 264.7 cells.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Chun KS / 2004 / Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention / Biochem Pharmacol 68 : 1089 ~ 1100
Eum WS / 2004 / HIV-1 Tat-mediated protein transduction of Cu,Zn-superoxide dismutase into pancreatic beta cells in vitro and in vivo / Free Radic Biol Med 37 : 339 ~ 349
Flohe L / 1997 / Redox regulation of NF-kappa B activation / Free Radic Biol Med 22 : 1115 ~ 1126
Gloire G / 2006 / NF-kappaB activation by reactive oxygen species: fifteen years later / Biochem Pharmacol 72 : 1493 ~ 1505
Guha M / 2001 / LPS induction of gene expression in human monocytes / Cell Signal 13 : 85 ~ 94
Eum WS / 2004 / HIV-1 Tat-mediated protein transduction of Cu,Zn-superoxide dismutase into pancreatic beta cells in vitro and in vivo / Free Radic Biol Med 37 : 339 ~ 349
Flohe L / 1997 / Redox regulation of NF-kappa B activation / Free Radic Biol Med 22 : 1115 ~ 1126
Gloire G / 2006 / NF-kappaB activation by reactive oxygen species: fifteen years later / Biochem Pharmacol 72 : 1493 ~ 1505
Guha M / 2001 / LPS induction of gene expression in human monocytes / Cell Signal 13 : 85 ~ 94
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Antiinflammatory Effect of Lactic Acid Bacteria: Inhibition of Cyclooxygenase-2 by Suppressing Nuclear Factor-κB in Raw264.7 Macrophage Cells
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Antiinflammatory Effects of New Chemical Compounds, HS-1580 Series(HS-1580, HS-1581, HS-1582)
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Superoxide dismutase의 활성차이에 따른 식물세포의 paraquat에 대한 반응과 핵 DNA 손상 검정
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Smilax guianensis Vitman Extract Prevents LPS-Induced Inflammation by Inhibiting the NF-κB Pathway in RAW 264.7 Cells
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Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism
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Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism
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