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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 778 - 786 (9page)
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초록· 키워드
오류제보하기
HIV-1 Tat is considered to be one of key players to facili-istic feature of AIDS-related encephalitis and de-mentia. This study was performed to determine the reg-ulatory function of superoxide dismutase (SOD) on the HIV-1 Tat-induced signaling pathways leading to NF-κB activation, expression of adhesion molecules, and monocyte adhesion in CRT-MG human as-troglioma cells by using cell-permeable SOD. When cell-permeable SOD was added to the culture medium time-dependent manners. Treatment of astrocytes with cell-permeable SOD led to decrease in Tat-in-duced ROS generation as well as NF-κB activation. Cell-permeable SOD inhibited the activation of MAP kinases including ERK, JNK and p38 by HIV-1 Tat. Treatment of CRT-MG cells with cell-permeable SOD significantly inhibited protein and mRNA levels of ICAM-1 and VCAM-1 up-regulated by HIV-1 Tat, as measured by Western blot analysis and RT-PCR. astrocyte by HIV-1 Tat was significantly abrogated by pretreatment with cell-permeable SOD fusion pro-teins. These data indicate that SOD has a regulatory function for HIV-1 Tat-induced NF-κB activation in as-trocytes and suggest that cell-permeable SOD can be used as a feasible therapeutic agent for regulation of ROS-related neurological diseases.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Badou A / 2000 / Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent path
Brenneisen P / 2002 / Ultraviolet- B irradiation and matrix metalloproteinases: from induction via signaling to initial events 973 : 31 ~ 43
Bruce-Keller AJ / 2001 / Pro-inflammatory and pro-oxidant properties of the HIV protein Tat in a microglial cell line: attenuation by 17 beta-estradiol 78 : 1315 ~ 1324
Choi C / 2002 / Tumor necrosis factor-related apoptosis-inducing ligand induces caspase-dependent interleukin-8 expression and apoptosis in human astroglioma cells 22 : 724 ~
Choi HS / 206 / PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model 41 : 1058 ~ 1068
Brenneisen P / 2002 / Ultraviolet- B irradiation and matrix metalloproteinases: from induction via signaling to initial events 973 : 31 ~ 43
Bruce-Keller AJ / 2001 / Pro-inflammatory and pro-oxidant properties of the HIV protein Tat in a microglial cell line: attenuation by 17 beta-estradiol 78 : 1315 ~ 1324
Choi C / 2002 / Tumor necrosis factor-related apoptosis-inducing ligand induces caspase-dependent interleukin-8 expression and apoptosis in human astroglioma cells 22 : 724 ~
Choi HS / 206 / PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model 41 : 1058 ~ 1068
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Extracellular HIV-1 Tat enhances monocyte adhesion byup-regulation of ICAM-1 and VCAM-1 gene expression viaROS-dependent NF-κB activation in astrocytes
Experimental and Molecular Medicine
2007 .01
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Extracellular HIV-1 Tat up-regulates expression of matrix metalloproteinase-9 via a MAPK-NF-κB dependent pathway in human astrocytes
Experimental and Molecular Medicine
2009 .01
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Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells
Experimental and Molecular Medicine
2009 .01
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Human Immunodeficiency Virus-1 Tat 단백에 의한 인간 CD99 유전자의 조절기전에 대한 연구
미생물학회지
2008 .12
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HIV-1 Latency and AIDS Pathogenesis in Association with p53 and HIV-1 Tat
한국미생물학회 학술대회논문집
2006 .05
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HIV-1 Tat Protein Promotes Amyloid β Generation and Tau Phosphorylation in Rat Hippocampal Slices
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2014 .03
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Characteristics of HIV-Tat Protein Transduction Domain
The Journal of Microbiology
2004 .12
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HIV-1 Tat Protein-dependent Cytotoxicity is Attenated by 15-deoxy-Delta12,14-Prostaglandin J2 in Rat Hippocampal Slices : Involvement of the ERK1/2 Signaling Pathway
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2013 .03
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Up-regulation of Galectin-3 in HIV-1 tat-transfected Cells
생명과학회지
2005 .04
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Effective Antibacterial Action of Tat (47-58) by Increased Uptake intoBacterial Cells in the Presence of Trypsin
Journal of Microbiology and Biotechnology
2008 .01
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Interaction Between Nucleocapsid and Tat protein of Human Immunodeficiency Virus Type 1 (HIV-1) and Its Effect on Tat-mediated Transcription
한국미생물학회 학술대회논문집
2011 .05
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High yields and soluble expression of superoxide dismutases in Escherichia coli due to the HIV-1 Tat peptide via increases in mRNA transcription
Experimental and Molecular Medicine
2016 .01
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Human Immunodeficiency Virus Type 1 Tat-Mediated Cellular Response in Myeloid Cells
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2014 .03
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Induced Degradation of Tat by NC via the Proteasome Pathway and Its Effect on HIV Transcription
한국미생물학회 학술대회논문집
2013 .05
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Degradation of Tat by NC via the Proteasome Pathway and Its Effect on HIV Transcription
한국미생물학회 학술대회논문집
2012 .05
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Enhancement of Gene Delivery Using Novel Homodimeric Tat Peptide Formed by Disulfide Bond
Journal of Microbiology and Biotechnology
2011 .01
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Regulation of HIV-1 Tat-dependent Transcription Elongation by Tat-SF1, DSIF and P-TEFb
한국미생물학회 학술대회논문집
2001 .11
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HIV-1 감염시 유도된 p53이 PKR 발현을 증가시키고 증가된 PKR이 Tat 활성을 억제함
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2004 .06
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청년기 자녀의 갈등에 관한 연구 : TAT를 통한 방법으로
가정과삶의질연구
1995 .03
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Pathway Analysis in HEK 293T Cells Overexpressing HIV-1 Tat and Nucleocapsid
Journal of Microbiology and Biotechnology
2009 .01
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