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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 656 - 664 (9page)
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Curcumin is a well known natural polyphenol product isolated from the rhizome of the plant Curcuma longa, anti-inflammatory agent for arthritis by inhibiting synthesis of inflammatory prostaglandins. However, the mechanisms by which curcumin regulates the functions of chondroprogenitor, such as proliferation, precartilage condensation, cytoskeletal organization or overall chondrogenic behavior, are largely unknown. In the present report, we investigated the effects and signaling mechanism of curcumin on the regulation of chondrogenesis. Treating chick limb bud mesenchymal cells with curcumin suppressed chondrogenesis by stimulating apoptotic cell death. It also inhibited reorganization of the actin cytoskeleton into a cortical pattern concomitant with rounding of chondrogenic competent cells and down-regulation of integrin β1 and focal adhesion kinase (FAK) phosphorylation.
Curcumin suppressed the phosphorylation of Akt leading to Akt inactivation. Activation of Akt by introducing a myristoylated, constitutively active form of Akt reversed the inhibitory actions of curcumin during chondrogenesis. In summary, for the first time, we describe biological properties of curcumin during chondrogenic differentiation of chick limb bud mesenchymal cells. Curcumin suppressed chondrogenesis by stimulating apoptotic cell death and down-regulating integrin-mediated reorganization of actin cytoskeleton via modulation of Akt signaling.
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참고문헌 (22)
참고문헌 신청
Bae JH / 2003 / Ruthenium red, inhibitor of mitochondrial Ca2+ uniporter, inhibits curcumin-induced apoptosis via the prevention of intracellular Ca2+ depletion and cytochrom
Balasubramanian S / 2006 / Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes / J Biol Chem 282 :
Bernt C / 2006 / The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis / Biochem Biophys Res Commun 340 : 800 ~ 806
Chang SH / 1998 / Protein kinase C regulates chondrogenesis of mesenchymes via mitogen-activated protein kinase signaling / J Biol Chem 273 : 19213 ~ 19219
Chen H / 1999 / Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells / Anticancer Res 19 : 3675 ~ 3680
Balasubramanian S / 2006 / Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes / J Biol Chem 282 :
Bernt C / 2006 / The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis / Biochem Biophys Res Commun 340 : 800 ~ 806
Chang SH / 1998 / Protein kinase C regulates chondrogenesis of mesenchymes via mitogen-activated protein kinase signaling / J Biol Chem 273 : 19213 ~ 19219
Chen H / 1999 / Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells / Anticancer Res 19 : 3675 ~ 3680
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Correction: Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells
Experimental and Molecular Medicine
2020 .01
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Curcumin이 인체대장암세포주인 SW480 cell에서 세포사멸에 미치는 영향
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Estimation of curcumin intake in Korea based on the Korea National Health and Nutrition Examination Survey (2008-2012)
Nutrition Research and Practice
2014 .10
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Estimation of curcumin intake in Korea based on the Korea National Health and Nutrition Examination Survey (2008-2012)
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2014 .10
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Pretreatment of curcumin protects hippocampal neurons against excitotoxin-induced cell death
생명과학회지
2007 .01
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Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion
Nutrition Research and Practice
2015 .04
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Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion
Nutrition Research and Practice
2015 .04
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Synthesis of Curcumin Glycosides with Enhanced Anticancer Properties Using One-Pot Multienzyme Glycosylation Technique
Journal of Microbiology and Biotechnology
2017 .01
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Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet
Nutrition Research and Practice
2010 .06
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Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet
Nutrition Research and Practice
2010 .06
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Determination of curcumin in rat plasma using UPLC-MS/MS and its application to a pharmacokinetic study of a novel curcumin formulation
한국분석과학회 학술대회
2018 .11
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Determination of curcumin in rat plasma using UPLC-MS/MS and its application to a pharmacokinetic study of a novel curcumin formulation
한국분석과학회 학술대회
2018 .11
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C57BL/6 마우스에서 고지방 식이와 CCl4로 유발한 간섬유증에 미치는 커큐민의 보호효과
대한임상검사과학회지
2015 .01
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Curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by STAT-3 signaling
Experimental and Molecular Medicine
2008 .01
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HCT116 대장암 세포에서 Akt-p53 신호경로를 통한 커큐민과 EGCG의 apoptosis 효과
생명과학회지
2011 .01
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Curcumin reduces cold storage-induced damage in humancardiac myoblasts
Experimental and Molecular Medicine
2007 .01
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Curcumin Inhibits Cell Proliferation of Human Colorectal HCT116 Cells through Up-Regulation of Activating Transcription Factor 3 (ATF3)
생명과학회지
2012 .04
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Regulation of Early Steps of Chondrogenesis in the Developing Limb
Animal cells and systems
2008 .01
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Signallings of Integrin-FAK Interaction for Cell Condensation during the Chondrogenesis of Chick Wing Bud Mesenchymal Cell
한국동물학회 학술대회
1997 .01
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Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets
Experimental and Molecular Medicine
2005 .01
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