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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 139 - 148 (10page)
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Curcumin is a polyphenolic compound possessing interesting anti-inflammatory and antioxidant pro-perties and has the ability to induce the defensive protein heme oxygenase-1 (HO-1). The objective of this study was to investigate whether curcumin protects against cold storage-mediated damage of human adult atrial myoblast cells (Girardi cells) and to assess the potential involvement of HO-1 in this process. Girardi cells were exposed to either normothermic or hypothermic conditions in Celsior preservation solution in the presence or absence of curcumin. HO-1 protein expression and heme oxygenase activity as well as cellular damage were by re-warming. In additional experiments, an in-hibitor of heme oxygenase activity (tin protopor-phyrin IX, 10 M) or siRNA for HO-1 were used to investigate the participation of HO-1 as a mediator of curcumin- induced effects. Treatment with curcumin produced a marked induction of cardiac HO-1 in normothermic condition but cells were less re-sponsive to the polyphenolic compound at low temperature. Cold storage-induced damage was markedly reduced in the presence of curcumin and HO-1 contributed to some extent to this effect. Thus, curcumin added to Celsior preservation solution effectively prevents the damage caused by cold- storage; this effect involves the protective enzyme HO-1 but also other not yet identified mechanisms.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Abuarqoub H / 2006 / Heme oxygenase-1 mediates the anti-inflammatory actions of 2'-hydroxychalcone in RAW 264.7 murine macrophages 290 : C1092 ~ C1099
Ahlenstiel T / 2006 / Improved cold preservation of kidney tubular cells by means of adding bioflavonoids to organ preservation solutions 81 : 231 ~ 239
Ammon HP / 1991 / Pharmacology of Curcuma longa 57 : 1 ~ 7
Balogun E / 2003a / Changes in temperature modulate heme oxygenase-1 induction by curcumin in renal epithelial cells 308 : 950 ~ 955
Balogun E / 2003b / Curcumin activates the heme oxy-genase-1 gene via regulation of Nrf2 and the antioxidant responsive element 371 : 887 ~ 895
Ahlenstiel T / 2006 / Improved cold preservation of kidney tubular cells by means of adding bioflavonoids to organ preservation solutions 81 : 231 ~ 239
Ammon HP / 1991 / Pharmacology of Curcuma longa 57 : 1 ~ 7
Balogun E / 2003a / Changes in temperature modulate heme oxygenase-1 induction by curcumin in renal epithelial cells 308 : 950 ~ 955
Balogun E / 2003b / Curcumin activates the heme oxy-genase-1 gene via regulation of Nrf2 and the antioxidant responsive element 371 : 887 ~ 895
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