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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 648 - 655 (8page)
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초록· 키워드
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Early stage diabetic nephropathy is characterized by
elevated glomerular filtration. Recent studies have identified
high-glucose induced p38 MAPK (p38) over-activation
in mesangial cells. Mesangial hypocontractility
is the major underlying mechanism, however, no ameliorating
agents are currently available. We investigated
the protective effects of emodin on high-glucose induced
mesangial cell hypocontractility. Mesangial cells
were cultured under normal (5.6 mM) and high glucose
(30 mM) conditions. Emodin was administrated at doses
of 50 mg/l and 100 mg/l. Angiotension II stimulated cell
surface reductions were measured to evaluate cell
contractility. p38 activity was detected using Western
blotting. To further explore the possible mechanism of
emodin, expression of the peroxisome proliferator- activated
receptor γ (PPARγ) was measured and its specific
inhibitor, gw9662, was administrated. Our results
showed: (1) high-glucose resulted in a 280% increase in
p38 activity associated with significant impairment of
mesangial contractility; (2) emodin treatment dose-dependently
inhibited high-glucose induced p38 over-activation
(a 40% decrease for 50 mg/l emodin and a 73%
decrease for 100 mg/l emodin), and mesangial hypocontractility
was ameriolated by emodin; (3) both the PPARγ
mRNA and protein levels were elevated after emodin
treatment; (4) inhibition of PPARγ using gw9662 effectively
blocked the ameliorating effects of emodin on
high-glucose induced p38 over-activation and mesangial
hypocontractility. Emodin effectively ameliorated
p38 over-activation and hypocontractility in
high-glucose induced mesangial cells, possibly via activation
of PPARγ.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Boileau C / 2007 / The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of oste
Chang CH / 1996 / Antiinflammatory effects of emodin from ventilago leiocarpa / The American Journal of Chinese Medicine 24 : 139 ~ 142
Chen JS / 2004 / Attenuation of mouse mesangial cell contractility by high glucose and mannitol: involvement of protein kinase C and focal adhesion kinase / J Biomed Sci 11 :
Derylo B / 1998 / High glucose-induced mesangial cell altered contractility: role of the polyol pathway / Diabetologia 41 : 507 ~ 515
Dunlop ME / 1990 / Insulin-dependent contractility of glomerular mesangial cells in response to angiotensin II, platelet activating factor and endothelin is attenuated by pro
Chang CH / 1996 / Antiinflammatory effects of emodin from ventilago leiocarpa / The American Journal of Chinese Medicine 24 : 139 ~ 142
Chen JS / 2004 / Attenuation of mouse mesangial cell contractility by high glucose and mannitol: involvement of protein kinase C and focal adhesion kinase / J Biomed Sci 11 :
Derylo B / 1998 / High glucose-induced mesangial cell altered contractility: role of the polyol pathway / Diabetologia 41 : 507 ~ 515
Dunlop ME / 1990 / Insulin-dependent contractility of glomerular mesangial cells in response to angiotensin II, platelet activating factor and endothelin is attenuated by pro
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