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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 101 - 110 (10page)
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In the present study, we show that the expression of type 2 glucose transporter isoform (GLUT2) could be regulated by PPAR-γ in the liver. Rosiglitazone, PPAR-γ agonist, activated the GLUT2 mRNA level in the primary cultured hepatocytes and Alexander cells, when these cells were transfected with PPAR-γ/RXR-α. We have localized the peroxisome proliferator response element in the mouse GLUT2 promoter by serial deletion studies and site-directed mutagenesis. Chromatin immunoprecipitation assay using ob/ob mice also showed that PPAR-γ rather than PPAR-α binds to the -197/-184 region of GLUT2 promoter. Taken together, liver GLUT2 may be a direct target of PPAR-γ ligand contributing to glucose transport into liver in a condition when PAPR-γ expression is increased as in type 2 diabetes or in severe
obesity.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
/ / A rapid and sensitive method for the quantitationof microgram quantities of protein utilizing the principleof protein-dye binding : 248 ~ 54
/ / A serum response element and abinding site for NF-Y mediate the serum response of the humanthrombospondin 1 gene : 4989 ~ 96
/ / Amultiplicity of CCAAT box-binding proteins : 863 ~ 72
/ / Tissue-specific in vitrotranscription from the mouse albumin promoter : 767 ~ 76
/ 19051-3 / The peroxisome proliferator-activated receptor mediates the induction of CYP4A6
/ / A serum response element and abinding site for NF-Y mediate the serum response of the humanthrombospondin 1 gene : 4989 ~ 96
/ / Amultiplicity of CCAAT box-binding proteins : 863 ~ 72
/ / Tissue-specific in vitrotranscription from the mouse albumin promoter : 767 ~ 76
/ 19051-3 / The peroxisome proliferator-activated receptor mediates the induction of CYP4A6
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Effects of d-α-tocopherol supplements on lipid metabolism in a high-fat diet-fed animal model
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