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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 638 - 647 (10page)
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초록· 키워드
오류제보하기
To investigate the potential role of microRNA (miRNA) in the regulation of circadian rhythm, we performed microarray-based expression profiling study of both miRNA and mRNA in mouse liver for 48 h at 4-hour intervals. Circadian miRNA-mRNA target pair is defined as the pair both elements of which show circadian expression patterns and the sequence-based target relationship of which can be predicted. Circadian initiators, Clock and Bmal1, showed inversely correlated circadian expression patterns against their corresponding miRNAs, miR-181d and miR-191, targeting them. In contrast, circadian suppressors, Per, Cry, CKIe and Rev-erba, exhibited positively correlated circadian expression patterns to their corresponding miRNAs. Genomic location analysis revealed that intronic region showed higher abundance of cyclic than non-cyclic miRNAs targeting circadian genes while other (i.e., 3'-UTR, exon and intergenic) regions showed no difference. It is suggested that miRNAs are involved in the regulation of peripheral circadian rhythm in mouse liver by modulating Clock:Bmal1 complex. Identifying specific miRNAs and their targets that are critically involved in circadian rhythm will provide a better understanding of the regulation of circadian-clock system.
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참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)]
Bartel DP / 2004 / MicroRNAs: genomics, biogenesis, mechanism, and function / Cell 116 : 281 ~ 297
Bolstad BM / 2003 / A comparison of normalization methods for high density oligonucleotide array data based on variance and bias / Bioinformatics 19 : 185 ~ 193
Bunger MK / 2000 / Mop3 is an essential component of the master circadian pacemaker in mammals / Cell 103 : 1009 ~ 1017
Cheng HY / 2007 / microRNA modulation of circadian-clock period and entrainment / Neuron 54 : 813 ~ 829
Bartel DP / 2004 / MicroRNAs: genomics, biogenesis, mechanism, and function / Cell 116 : 281 ~ 297
Bolstad BM / 2003 / A comparison of normalization methods for high density oligonucleotide array data based on variance and bias / Bioinformatics 19 : 185 ~ 193
Bunger MK / 2000 / Mop3 is an essential component of the master circadian pacemaker in mammals / Cell 103 : 1009 ~ 1017
Cheng HY / 2007 / microRNA modulation of circadian-clock period and entrainment / Neuron 54 : 813 ~ 829
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