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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 746 - 756 (11page)
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Coronaviruses (CoVs) are single-stranded RNA viruses
which contain the largest RNA genomes, and severe
acute respiratory syndrome coronavirus
(SARS-CoV), a newly found group 2 CoV, emerged as
infectious disease with high mortality rate. In this
study, we compared the synonymous codon usage
patterns between the nucleocapsid and spike genes of
CoVs, and C-type lectin domain (CTLD) genes of human
and mouse on the codon basis. Findings indicate
that the nucleocapsid genes of CoVs were affected
from the synonymous codon usage bias than spike
genes, and the CTLDs of human and mouse partially
overlapped with the nucleocapsid genes of CoVs. In
addition, we observed that CTLDs which showed the
similar relative synonymous codon usage (RSCU) patterns
with CoVs were commonly derived from the human
chromosome 12, and mouse chromosome 6 and
12, suggesting that there might be a specific genomic
region or chromosomes which show a more similar
synonymous codon usage pattern with viral genes.
Our findings contribute to developing the codon-optimization
method in DNA vaccines, and further study is
needed to determine a specific correlation between the
codon usage patterns and the chromosomal locations
in higher organisms.
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참고문헌 (28)
참고문헌 신청
[학술지(정기간
Ahn I / 2006 / Genomic analysis of influenza A viruses, including avian flu (H5N1) strains / Eur J Epidemiol 21 : 511 ~ 519
Ahn I / 2007 / Comparative study of the hemagglutinin and neuraminidase genes of influenza A virus H3N2, H9N2, and H5N1 subtypes using bioinformatics techniques / Can J Micro
Bode JG / 2003 / IFN-α antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3 / FASEB J 17 : 488 ~ 490
Cary NC / 2004 / SAS 9.1.2 Qualification Tolls User’s Guide / SAS Institute Inc
Ahn I / 2006 / Genomic analysis of influenza A viruses, including avian flu (H5N1) strains / Eur J Epidemiol 21 : 511 ~ 519
Ahn I / 2007 / Comparative study of the hemagglutinin and neuraminidase genes of influenza A virus H3N2, H9N2, and H5N1 subtypes using bioinformatics techniques / Can J Micro
Bode JG / 2003 / IFN-α antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3 / FASEB J 17 : 488 ~ 490
Cary NC / 2004 / SAS 9.1.2 Qualification Tolls User’s Guide / SAS Institute Inc
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Detection of Heterozygous Truncating Mutations in the StAR Gene by Using Stop Codon Assay in E.coli
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