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Middle East respiratory syndrome coronavirus (MERS-CoV) causes high fever, cough, acute respiratory tract infection and multiorgan dysfunction that may eventually lead to the death of the infected individuals. MERS-CoV is thought to be transmitted to humans through dromedary camels. The occurrence of the virus was first reported in the Middle East and it subsequently spread to several parts of the world. Since 2012, about 1368 infections, including ~ 487 deaths, have been reported worldwide. Notably, the recent human-to-human ‘superspreading’ of MERS-CoV in hospitals in South Korea has raised a major global health concern. The fatality rate in MERS-CoV infection is four times higher compared with that of the closely related severe acute respiratory syndrome coronavirus infection. Currently, no drug has been clinically approved to control MERS-CoV infection. In this study, we highlight the potential drug targets that can be used to develop anti-MERS-CoV therapeutics.
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참고문헌 (25)
참고문헌 신청
[학술지
Al-Tawfiq JA / 2014 / Middle East respiratory syndrome coronavirus : transmission and phylogenetic evolution / Trends Microbiol 22 : 573 ~ 579
Baez-Santos YM / 2014 / Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus / J Viro
Bailey-Elkin BA / 2014 / Crystal structure of the Middle East respiratory syndrome coronavirus(MERS-CoV)papain-like protease bound to ubiquitin facilitates targeted disrupti
Banik GR / 2015 / Middle East Respiratory Syndrome Coronavirus ‘MERS-CoV’ : current knowledge gaps / Paediatr Respir Rev 16 : 197 ~ 202
Al-Tawfiq JA / 2014 / Middle East respiratory syndrome coronavirus : transmission and phylogenetic evolution / Trends Microbiol 22 : 573 ~ 579
Baez-Santos YM / 2014 / Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus / J Viro
Bailey-Elkin BA / 2014 / Crystal structure of the Middle East respiratory syndrome coronavirus(MERS-CoV)papain-like protease bound to ubiquitin facilitates targeted disrupti
Banik GR / 2015 / Middle East Respiratory Syndrome Coronavirus ‘MERS-CoV’ : current knowledge gaps / Paediatr Respir Rev 16 : 197 ~ 202
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MERS-CoV의 감염 동역학 분석 연구
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Evaluation of the basic reproduction number of MERS-CoV during the 2015 Outbreak in South Korea
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Safety and Effectiveness Evaluation Standards for MERS-CoV Nucleic Acid-Based Detection assays
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MERS 사태에 대한 대응 네트워크 분석
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2018 .12
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Detection of Middle East Respiratory Syndrome Coronavirus by using One-step reverse transcription Loop-Mediated Isothermal Amplification (RT-LAMP)
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중심-주변 구조 탐지 기법을 이용한 MERS 대응 네트워크 분석
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SARS-CoV, MERS-CoV, SARS-CoV-2 (COVID-19) 관련 뉴스 빅데이터 비교 분석
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On the origin and evolution of SARS-CoV-2
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Detection of Severe Acute Respiratory Syndrome Coronavirus 2 Using Graphene-based Biosensor
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2021 .04
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Competitive Immunoassay of SARS‑CoV‑2 Using Pig Sera‑Derived Anti‑SARS‑CoV‑2 Antibodies
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2021 .01
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From bedside to bench: regulation of host factors in SARS-CoV-2 infection
Experimental and Molecular Medicine
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Pig Sera-derived Anti-SARS-CoV-2 Antibodies with Controlled Specificity for Competitive Immunoassay
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2021 .04
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SARS VS MERS VS COVID-19
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2022 .04
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보건의료 분야 재난대응 원칙으로 본 중동호흡기 증후군(MERS-CoV) 대응
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2015 .01
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중증 호흡기 감염병 진료를 고려한 음압격리병동부의 건축계획
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Phylogenetic Relationship of the Complete SARS-CoV-2 Genome Sequences
한국생물공학회 학술대회
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