지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 10 (10page)
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초록· 키워드
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A limited number of microRNAs (miRNAs, miRs) have been reported to control postnatal cardiomyocyte proliferation, but their strong regulatory effects suggest a possible therapeutic approach to stimulate regenerative capacity in the diseased myocardium.
This study aimed to investigate the miRNAs responsible for postnatal cardiomyocyte proliferation and their downstream targets.
Here, we compared miRNA profiles in cardiomyocytes between postnatal day 0 (P0) and day 10 (P10) using miRNA arrays, and found that 21 miRNAs were upregulated at P10, whereas 11 were downregulated. Among them, miR-31a-5p was identified as being able to promote cardiomyocyte proliferation as determined by proliferating cell nuclear antigen (PCNA) expression, double immunofluorescent labeling for α-actinin and 5-ethynyl-2-deoxyuridine (EdU) or Ki-67, and cell number counting, whereas miR-31a-5p inhibition could reduce their levels. RhoBTB1 was identified as a target gene of miR-31a-5p, mediating the regulatory effect of miR-31a-5p in cardiomyocyte proliferation. Importantly, neonatal rats injected with a miR-31a-5p antagomir at day 0 for three consecutive days exhibited reduced expression of markers of cardiomyocyte proliferation including PCNA expression and double immunofluorescent labeling for α-actinin and EdU, Ki-67 or phospho-histone-H3. In conclusion, miR-31a-5p controls postnatal cardiomyocyte proliferation by targeting RhoBTB1, and increasing miR-31a-5p level might be a novel therapeutic strategy for enhancing cardiac reparative processes.
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참고문헌 (27)
참고문헌 신청
Boon RA / 2015 / Micrornas in myocardial infarction / Nat Rev Cardiol 12 : 135 ~ 142
Bronnum H / 2013 / Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells / Exp Cell Res 319 : 424 ~ 435
Cao X / 2013 / Microrna profiling during rat ventricular maturation : a role for mir-29a in regulating cardiomyocyte cell cycle re-entry / FEBS Lett 587 : 1548 ~ 1555
Cheung CC / 2014 / Mir-31 is consistently inactivated in ebv-associated nasopharyngeal carcinoma and contributes to its tumorigenesis / Mol Cancer 13 : 184 ~
De Rosa S / 2014 / Emerging role of micrornas in cardiovascular diseases / Circ J 78 : 567 ~ 575
Bronnum H / 2013 / Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells / Exp Cell Res 319 : 424 ~ 435
Cao X / 2013 / Microrna profiling during rat ventricular maturation : a role for mir-29a in regulating cardiomyocyte cell cycle re-entry / FEBS Lett 587 : 1548 ~ 1555
Cheung CC / 2014 / Mir-31 is consistently inactivated in ebv-associated nasopharyngeal carcinoma and contributes to its tumorigenesis / Mol Cancer 13 : 184 ~
De Rosa S / 2014 / Emerging role of micrornas in cardiovascular diseases / Circ J 78 : 567 ~ 575
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