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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 812 - 819 (8page)
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초록· 키워드
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A degree of brain inflammation is required for repair of
damaged tissue, but excessive inflammation causes
neuronal cell death. Here, we observe that IL-10 is expressed
in LPS-injected rat cerebral cortex, contributing
to neuronal survival. Cells immunopositive
for IL-10 were detected as early as 8 h post-injection and
persisted for up to 3 d, in parallel with the expression
of IL-1β, TNF-α , and iNOS. Double immunofluorescence
staining showed that IL-10 expression was localized
mainly in activated microglia. Next, we examined
the neuroprotective effects of IL-10 using IL-10
neutralizing antibody (IL-10NA). Blockade of IL-10 action
caused a significant loss of neurons both 3 d and
7 d after LPS injection. Further, the induction of mRNA
species encoding IL-1β, TNF-α , and iNOS, reactive
oxygen species (ROS) production, and NADPH oxidase
activation, increased after co-injection of LPS and
IL-10NA, compared to the levels seen after injection of
LPS alone. Taken together, these results clearly suggest
that LPS-induced endogenous expression of
IL-10 in microglia contributes to neuronal survival by
inhibiting brain inflammation.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Allan SM / 2001 / Cytokines and acute neurode-generation 2 : 734 ~ 744
Aloisi F / 1997 / IL-12 production by central nervous system microglia is inhibited by astrocytes 159 : 1604 ~ 1612
Aloisi F / 1999a / Opposite effects of interferon- γ and prostaglandin E2 on tumor necrosis factor and interleukin-10 production in microglia: a regulatory loop controlling
Aloisi F / 1999b / CD40- CD154 interaction and IFN- γ are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells 162 : 1
Aloisi F / 2001 / Immune function of microglia 36 : 165 ~ 179
Aloisi F / 1997 / IL-12 production by central nervous system microglia is inhibited by astrocytes 159 : 1604 ~ 1612
Aloisi F / 1999a / Opposite effects of interferon- γ and prostaglandin E2 on tumor necrosis factor and interleukin-10 production in microglia: a regulatory loop controlling
Aloisi F / 1999b / CD40- CD154 interaction and IFN- γ are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells 162 : 1
Aloisi F / 2001 / Immune function of microglia 36 : 165 ~ 179
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