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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 343 - 352 (10page)
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Asthma was induced by th e sensitization and chal-lenge with ovalbumin (OVA) in mice. B-cell activating factor (BAFF) plays a role in mature B cell generation BAFF expression was change d in OVA-induced mice and whether the control of BAFF expression level alleviates the symptom of bronchial asthma. BAFF expression was detected in alveolar-associated cells surrounding bronchi of OVA-induced mouse lung tissues. BAFF protein was also increased in OVA-induced mouse serum. The increased BAFF transcripts was detected in OVA-induced mouse splenocytes. OVA-induced asthma was associated with the increased number of eosinophils in bron-choalveolar lavage fluid ( BALF). When TACI:Fc scav-enging soluble BAFF was in jected to OVA-induced mice, a significant inhibition was detected in the thickness of airway smooth muscle and glycol-con-taining cellular elements in airway that were vi-sualized by hematoxylin/eosin Y and periodic acid-Schiff staining, respectively. In addition, when mice were treated with TAtein level was decreased in alveolar-associated cells surrounding bronchi of OVA-induced mouse lung tissues compared to control mice. When compared to OVA-induced control, TACI:Fc treatment reduced the percentage of non-lymphoid cells and no changes were detected in lymphoid cell population. Hypodiploid cell formation in BALF was decreased by OVA-challenge but it was recovered by TACI:Fc treatment. Collectively, data suggest that asthmatic symptom could be alleviated by scavenging BAFF and then BAFF could be a novel target for the devel-opment of anti-asthmatic agents.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
/ actapaediatrscand1985;74 / Non-IgE-mediated asthma in children : 713 ~ 9
/ amjmed1947;33 / A working classification of asthma : 601 ~ 6
Bonacci JV / 2006 / Collagen impairs glucocorticoid actions in airway smooth muscle through integrin signalling 149 : 365 ~ 373
Chae SC / 2004 / Molecular variations in Th1-specific cell surface gene Tim-3 36 : 274 ~ 278
Cho YS / 2006 / 4-1 BB stimulation inhibits allergen- specific immunoglobulin E production and airway hyper- reactivity but partially suppresses bronchial eosinophilic inflam
/ amjmed1947;33 / A working classification of asthma : 601 ~ 6
Bonacci JV / 2006 / Collagen impairs glucocorticoid actions in airway smooth muscle through integrin signalling 149 : 365 ~ 373
Chae SC / 2004 / Molecular variations in Th1-specific cell surface gene Tim-3 36 : 274 ~ 278
Cho YS / 2006 / 4-1 BB stimulation inhibits allergen- specific immunoglobulin E production and airway hyper- reactivity but partially suppresses bronchial eosinophilic inflam
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