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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 208 - 216 (9page)
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초록· 키워드
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B cell activation factor (BAFF) is a novel member of the
TNF ligand superfamily, mainly produced by myeloid
cells. BAFF has been shown to participate in B-cell survival
and B- and T-cell maturation. BAFF expression in
adipocytes has been recently demonstrated. In the current
study, we verified that BAFF expression is increased
during adipocyte differentiation. BAFF expression
was augmented by TNF-α treatment and was
decreased by rosiglitazone treatment. BAFF secretion
in lean and in ob/ob mice sera were compared and
smaller amount of BAFF was secreted in ob/ob mice.
mRNA and protein expression were different between
epididymal and visceral adipose tissue. BAFF expression
was also increased in ob/ob mouse adipose
tissue. We sought to identify known BAFF receptors
(BAFF-R, BCMA, and TACI) in adipocytes, and determined
that all three were present and upregulated
during adipocyte differentiation. However, the expression
of TACI was distinct from that of BAFF-R and
BCMA under TNF-α and BAFF ligand treatment.
BAFF-R and BCMA expression levels were upregulated
under pro-inflammatory conditions, but TACI
was reduced. Conversely, BAFF-R and BCMA expression
levels were downregulated by rosiglitazone
treatment, but TACI was increased. Taken together,
our results suggest that BAFF may be a new adipokine,
representing a link between obesity and inflammation.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Craxton A / 2003 / Macrophage- and dendritic cell-dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF / Blood 101 : 4464 ~ 4471
Fantuzzi G / 2005 / Adipose tissue, adipokines and inflammation / J Allergy Clin Immunol 115 : 911 ~ 919
Gross JA / 2000 / TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease / Nature 404 : 995 ~ 999
Haiat S / 2006 / Ajchenbaum-Cymbalista F, Kolb JP. Role of BAFF and APRIL in human B-cell chronic lymphocytic leukaemia / Immunology 118 : 281 ~ 292
Huard B / 2001 / French LE. T cell costimulation by the TNF ligand BAFF / J Immunol 167 : 6225 ~ 6231
Fantuzzi G / 2005 / Adipose tissue, adipokines and inflammation / J Allergy Clin Immunol 115 : 911 ~ 919
Gross JA / 2000 / TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease / Nature 404 : 995 ~ 999
Haiat S / 2006 / Ajchenbaum-Cymbalista F, Kolb JP. Role of BAFF and APRIL in human B-cell chronic lymphocytic leukaemia / Immunology 118 : 281 ~ 292
Huard B / 2001 / French LE. T cell costimulation by the TNF ligand BAFF / J Immunol 167 : 6225 ~ 6231
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