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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 19 - 26 (8page)
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초록· 키워드
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Previously we demonstrated that ATP released from
LPS-activated microglia induced IL-10 expression in a
process involving P2 receptors, in an autocrine
fashion. Therefore, in the present study we sought to
determine which subtype of P2 receptor was responsible
for the modulation of IL-10 expression in
ATP-stimulated microglia. We found that the patterns
of IL-10 production were dose-dependent (1, 10, 100,
1,000 µM) and bell-shaped. The concentrations of ATP,
ATP-γS, ADP, and ADP-β S that showed maximal IL-10
release were 100, 10, 100, and 100 µM respectively. The
rank order of agonist potency for IL-10 production was
2'-3'-O-(4-benzoyl)-benzoyl ATP (BzATP) = dATP ＞
2-methylthio-ADP (2-meSADP). On the other hand,
2-methylthio-ATP (2-meSATP), α,β-methylene ATP
(α,β-meATP), UTP, and UDP did not induce the release
of IL-10 from microglia. Further, we obtained evidence
of crosstalk between P2 receptors, in a situation where
intracellular Ca2+ release and/or cAMP-activated PKA
were the main contributors to extracellular ATP-(orADP)-mediated IL-10 expression, and IL-10 production
was down- regulated by either MRS2179 (a P2Y1 antagonist)
or 5'-AMPS (a P2Y11 antagonist), indicating that
both the P2Y1 and P2Y11 receptors are major receptors
involved in IL-10 expression. In addition, we found that
inhibition of IL-10 production by high concentrations
of ATP-γS (100 µM) was restored by TNP-ATP (an antagonist
of the P2X1, P2X3, and P2X4 receptors), and that
IL-10 production by 2-meSADP was restored by
2meSAMP (a P2Y12 receptor antagonist) or pertussis
toxin (PTX; a Gi protein inhibitor), indicating that the
P2X1, P2X3, P2X4 receptor group, or the P2Y12 receptor,
negatively modulate the P2Y11 receptor or the P2Y1 receptor,
respectively.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)]
Abbracchio MP / 2006 / International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to t
Aloisi F / 1999 / Opposite effects of interferon-γ and prostaglandin E2 on tumor necrosis factor and interleukin-10 production in microglia: a regulatory loop controlling mi
Brunschweiger A / 2006 / P2 receptors activated by uracil nucleotides--an update / Curr Med Chem 13 : 289 ~ 312
Communi D / 1995 / Cloning and functional expression of a human uridine nucleotide receptor / J Biol Chem 270 : 30849 ~ 52
Abbracchio MP / 2006 / International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to t
Aloisi F / 1999 / Opposite effects of interferon-γ and prostaglandin E2 on tumor necrosis factor and interleukin-10 production in microglia: a regulatory loop controlling mi
Brunschweiger A / 2006 / P2 receptors activated by uracil nucleotides--an update / Curr Med Chem 13 : 289 ~ 312
Communi D / 1995 / Cloning and functional expression of a human uridine nucleotide receptor / J Biol Chem 270 : 30849 ~ 52
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