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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 759 - 767 (9page)
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The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how this oncogene contributes to tumorigenesis remains unclear. Here we demonstrate that Aurora-A overexpression enhances both the expression level and transcriptional activity of c-Myc.
The inhibition of c-Myc expression by RNA interference significantly impaired the oncogenic potential of Aurora-A, resulting in attenuated cellular proliferation and transformation rates as well as fewer centrosomal aberrations. Furthermore, downregulation of c-Myc effectively overcame Aurora-A-induced resistance to cisplatin in esophageal cancer cells. Taken together,our results suggest an important role for c-Myc in mediating the oncogenic activity of Aurora-A, which may in turn allow for future targeting of c-Myc as a potential therapeutic strategy for tumors with Aurora-A overexpression.
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참고문헌 (24)
참고문헌 신청
Anand S / 2003 / AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol / Cancer Cell 3 : 51 ~ 62
Bischoff JR / 1998 / A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers / EMBO J 17 : 3052 ~ 3065
Dang CV / 1999 / c-Myc target genes involved in cell growth, apoptosis, and metabolism / Mol Cell Biol 19 : 1 ~ 11
Dar AA / 2009 / The aurora kinase A regulates GSK-3beta in gastric cancer cells / Oncogene 28 : 866 ~ 875
Ditchfield C / 2003 / Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores / J Cell Biol 161 : 267 ~ 280
Bischoff JR / 1998 / A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers / EMBO J 17 : 3052 ~ 3065
Dang CV / 1999 / c-Myc target genes involved in cell growth, apoptosis, and metabolism / Mol Cell Biol 19 : 1 ~ 11
Dar AA / 2009 / The aurora kinase A regulates GSK-3beta in gastric cancer cells / Oncogene 28 : 866 ~ 875
Ditchfield C / 2003 / Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores / J Cell Biol 161 : 267 ~ 280
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