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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 435 - 444 (10page)
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초록· 키워드
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Repeated electroconvulsive seizure (ECS), a model for electroconvulsive therapy (ECT), exerts neuroprotective and proliferative effects in the brain. This trophic action of ECS requires inhibition of apoptotic activity, in addition to activation of survival signals.
c-Myc plays an important role in apoptosis of neurons, in cooperation with the Bcl-2 family proteins, and its activity and stability are regulated by phosphorylation and ubiquitination. We examined c-Myc and related proteins responsible for apoptosis after repeated ECS.
In the rat frontal cortex, repeated ECS for 10 days reduced the total amount of c-Myc, while increasing phosphorylation of c-Myc at Thr58, which reportedly induces degradation of c-Myc. As expected, ubiquitination of both phosphorylated and total c-Myc increased after 10 days ECS, suggesting that ECS may reduce c-Myc protein level via ubiquitination-proteasomal degradation. Bcl-2 family proteins, caspase, and poly(ADP-ribose) polymerase (PARP) were investigated to determine the consequence of down-regulating c-Myc. Protein levels of Bcl-2, Bcl-XL, Bax, and Bad showed no change, and cleavage of caspase-3 and PARP were not induced. However, phosphorylation of Bad at Ser-155 and binding of Bad to 14-3-3 increased without binding to Bcl-XL after repeated ECS, implying that repeated ECS sequesters apoptotic Bad and frees pro-survival Bcl-XL. Taken together, c-Myc down-regulation via ubiquitination-proteasomal degradation and Bad inactivation by binding to 14-3-3 may be anti-apoptotic mechanisms elicited by repeated ECS in the rat frontal cortex. This finding further supports the trophic effect of ECS blocking apoptosis as a possible therapeutic effect of ECT.
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참고문헌 (24)
참고문헌 신청
Akiyama K / 1994 / Methamphetamine- induced behavioral sensitization and its implications for relapse of schizophrenia / Schizophr Res 12 : 251 ~ 7
Altar CA / 2004 / Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways / J Neurosci 24 : 2667 ~ 77
Benes FM / 2006 / The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia / Mol Psychiatry 11 : 241 ~ 51
Busnello JV / 2006 / Acute and chronic electroconvulsive shock in rats: effects on peripheral markers of neuronal injury and glial activity / Life Sci 78 : 3013 ~ 7
Datta SR / 1997 / Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery / Cell 91 : 231 ~ 41
Altar CA / 2004 / Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways / J Neurosci 24 : 2667 ~ 77
Benes FM / 2006 / The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia / Mol Psychiatry 11 : 241 ~ 51
Busnello JV / 2006 / Acute and chronic electroconvulsive shock in rats: effects on peripheral markers of neuronal injury and glial activity / Life Sci 78 : 3013 ~ 7
Datta SR / 1997 / Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery / Cell 91 : 231 ~ 41
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