지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1 - 11 (11page)
이용수
초록· 키워드
오류제보하기
In several human tumors, signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB (NFκB) are activated and interact; how these STAT3–NFκB complexes are transported to the nucleus is not fully understood. In this study, we found that Rac1 was activated in starved cancer cells and that activated Rac1 coexisted with STAT3 and NFκB. Rac1 knockdown and overexpression of the dominant-negative mutant Rac1N19 inhibited the degradation of IκBα, an inhibitor of NFκB. MG132, an inhibitor of the ubiquitin proteasome pathway, increased the amount of non-phosphorylated IκBα, but not serine-phosphorylated IκBα, indicating that IκBα degradation by Rac1 in starved cancer cells is independent of IκBα serine phosphorylation by IKK. Rac1 knockdown also inhibited the nuclear translocation of STAT3–NFκB complexes, indicating that this translocation requires activated Rac1. We also demonstrated that the mutant STAT3 Y705F could form complexes with NFκB, and these unphosphorylated STAT3–NFκB complexes translocated into the nucleus and upregulated the activity of NFκB in starved cancer cells, suggesting that phosphorylation of STAT3 is not essential for its translocation. To our knowledge, this is the first study demonstrating the crucial role of Rac1 in the function of STAT3–NFκB complexes in starved cancer cells and implies that targeting Rac1 may have future therapeutic significance in cancer therapy.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Analysis on the dynamic characteristics of RAC frame structures
Structural Engineering and Mechanics, An Int＇l Journal
2017 .01
-
Analysis on the dynamic characteristics of RAC frame structures
Structural engineering and mechanics : An international journal
2017 .01
-
Highlighted STAT3 as a potential drug target for cancer therapy
BMB Reports
2019 .01
-
Stat2 stability regulation: an intersection between immunity and carcinogenesis
Experimental and Molecular Medicine
2020 .09
-
Alternative regulatory mechanism for the maintenance of bone homeostasis via STAT5-mediated regulation of the differentiation of BMSCs into adipocytes
Experimental and Molecular Medicine
2021 .05
-
Regulation of signal transducer and activator of transcription 3 activation by dual-specificity phosphatase 3
BMB Reports
2020 .01
-
Micro-concrete composites for strengthening of RC frame made of recycled aggregate concrete
Computers and Concrete, An International Journal
2018 .01
-
Behaviour of recycled aggregate concrete beam-column connections in presence of PET fibers at the joint region
Computers and Concrete, An International Journal
2018 .01
-
Seismic Analysis on Recycled Aggregate Concrete Frame Considering Strain Rate Effect
International Journal of Concrete Structures and Materials
2016 .09
-
Long-Term Flexural Behaviour of Cracked Reinforced Concrete Beams with Recycled Aggregate
International Journal of Concrete Structures and Materials
2022 .05
-
가정용 에어컨 냉매 누설량 분류모델 개발
대한기계학회 춘추학술대회
2021 .08
-
Simulation study on dynamic response of precast frames made of recycled aggregate concrete
Computers and Concrete, An International Journal
2015 .01
-
Modulation of IL-6 via STAT3 signaling in the EC-18 treated cell
한국생물공학회 학술대회
2015 .04
-
Lysophosphatidic acid increases mesangial cell proliferation in models of diabetic nephropathy via Rac1/MAPK/KLF5 signaling
Experimental and Molecular Medicine
2019 .01
-
Experimental Study on Tensile Creep of Coarse Recycled Aggregate Concrete
International Journal of Concrete Structures and Materials
2015 .09
-
LMO2-LDB1 Transcriptional Mediator Activates STAT3 Signaling via GP130-dimerization in Glioblastoma Stem Cells
한국생물공학회 학술대회
2021 .10
-
NF₃ 가수분해반응에서의 불화된 금속산화물의 활성평가
한국에너지기후변화학회 학술대회
2016 .11
-
Hyaluronic Acid Decorated Nanofiber Fragment Scaffold for Corneal Regeneration
한국고분자학회 학술대회 연구논문 초록집
2021 .10
-
Synergistic Effects of Polypropylene and Glass Fiber on Mechanical Properties and Durability of Recycled Aggregate Concrete
International Journal of Concrete Structures and Materials
2020 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0