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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 415 - 423 (9page)
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초록· 키워드
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Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription factor that regulates cell proliferation, differentiation, apoptosis, angiogenesis, inflammation and immune responses. Aberrant STAT3 activation triggers tumor progression through oncogenic gene expression in numerous human cancers, leading to promote tumor malignancy. On the contrary, STAT3 activation in immune cells cause elevation of immunosuppressive factors. Accumulating evidence suggests that the tumor microenvironment closely interacts with the STAT3 signaling pathway. So, targeting STAT3 may improve tumor progression, and anti-cancer immune response. In this review, we summarized the role of STAT3 in cancer and the tumor microenvironment, and present inhibitors of STAT3 signaling cascades.
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참고문헌 (32)
참고문헌 신청
Zhang X / 2013 / A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation / Cancer Res 73:1922~1933
Kumar A / 2012 / Molecular docking studies on inhibition of Stat3 dimerization by curcumin natural derivatives and its conjugates with amino acids / Bioinformation 8:988~993
Shin D-S / 2009 / Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells / Cancer Res 69:193~202
Song H / 2005 / A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells / Proc Natl Acad Sci U S A 102:4700~4705
Schust J / 2006 / Stattic : A Small-Molecule Inhibitor of STAT3 Activation and Dimerization / Chem Biol 13:1235~1242
Kumar A / 2012 / Molecular docking studies on inhibition of Stat3 dimerization by curcumin natural derivatives and its conjugates with amino acids / Bioinformation 8:988~993
Shin D-S / 2009 / Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells / Cancer Res 69:193~202
Song H / 2005 / A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells / Proc Natl Acad Sci U S A 102:4700~4705
Schust J / 2006 / Stattic : A Small-Molecule Inhibitor of STAT3 Activation and Dimerization / Chem Biol 13:1235~1242
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