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- 2017.1
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Given that increased thermogenesis in white adipose tissue, also known as browning, promotes energy expenditure, significant efforts have been invested to determine the molecular factors involved in this process. Here we show that HOXC10, a homeobox domain-containing transcription factor expressed in subcutaneous white adipose tissue, is a suppressor of genes involved in browning white adipose tissue. Ectopic expression of HOXC10 in adipocytes suppresses brown fat genes, whereas the depletion of HOXC10 in adipocytes and myoblasts increases the expression of brown fat genes. The protein level of HOXC10 inversely correlates with brown fat genes in subcutaneous white adipose tissue of cold-exposed mice. Expression of HOXC10 in mice suppresses cold-induced browning in subcutaneous white adipose tissue and abolishes the beneficial effect of cold exposure on glucose clearance. HOXC10 exerts its effect, at least in part, by suppressing PRDM16 expression. The results support that HOXC10 is a key negative regulator of the process of browning in white adipose tissue.
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참고문헌 (23)
참고문헌 신청
Ansari KI / 2012 / HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4 / J Mol Endocrino
Brune JE / 2016 / Fat depot-specific expression of HOXC9 and HOXC10 may contribute to adverse fat distribution and related metabolic traits / Obesity(Silver Spring) 24 : 51
Carlson MR / 2001 / Expression of Hoxb13 and Hoxc10 in developing and regenerating Axolotl limbs and tails / Dev Biol 229 : 396 ~ 406
Cederberg A / 2001 / FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance / Cell 106 : 563 ~ 573
Chen EY / 2013 / Enrichr : interactive and collaborative HTML5 gene list enrichment analysis tool / BMC Bioinformatics 14 : 128 ~
Brune JE / 2016 / Fat depot-specific expression of HOXC9 and HOXC10 may contribute to adverse fat distribution and related metabolic traits / Obesity(Silver Spring) 24 : 51
Carlson MR / 2001 / Expression of Hoxb13 and Hoxc10 in developing and regenerating Axolotl limbs and tails / Dev Biol 229 : 396 ~ 406
Cederberg A / 2001 / FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance / Cell 106 : 563 ~ 573
Chen EY / 2013 / Enrichr : interactive and collaborative HTML5 gene list enrichment analysis tool / BMC Bioinformatics 14 : 128 ~
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