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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 841 - 848 (8page)
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초록· 키워드
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The QTc interval is a complex quantitative trait and a strong prognostic indicator of cardiovascular mortality in general, healthy people. The aim of this study was to identify non-genetic factors and quantitative trait loci that govern the QTc interval in an isolated Mongolian population. We used multiple regression analysis to determine the relationship between the QTc interval and non-genetic factors including height, blood pressure, and the plasma lipid level. Whole genome linkage analyses were performed to reveal quantitative trait loci for the QTc interval with 349 microsatellite markers from 1,080 Mongolian subjects. Among many factors previously known for association with the QTc interval, age, sex, heart rate, QRS duration of electrocardiogram and systolic blood pressure were also found to have influence on the QTc interval. A genetic effect for the QTc interval was identified based on familial correlation with a heritability value of 0.31. In a whole genome linkage analysis, we identified the four potential linkage regions 7q31-34, 5q21, 4q28, and 2q36.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Algra A / 1991 / QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest / Circulation 83 : 188
Almasy L / 1998 / Multipoint quantitative-trait linkage analysis in general pedigrees / Am J Hum Genet 62 : 1198 ~ 1211
Bayasgalan Gombojav / 2008 / Heritability and linkage study on heart rates in a Mongolian population / Experimental and Molecular Medicine 40 (5) : 559 ~ 565
Bednar MM / 2001 / The QT interval / Prog Cardiovasc Dis 43 : 1 ~ 45
Benoit SR / 2005 / Risk factors for prolonged QTc among US adults: Third National Health and Nutrition Examination Survey / Eur J Cardiovasc Prev Rehabil : 368 ~
Almasy L / 1998 / Multipoint quantitative-trait linkage analysis in general pedigrees / Am J Hum Genet 62 : 1198 ~ 1211
Bayasgalan Gombojav / 2008 / Heritability and linkage study on heart rates in a Mongolian population / Experimental and Molecular Medicine 40 (5) : 559 ~ 565
Bednar MM / 2001 / The QT interval / Prog Cardiovasc Dis 43 : 1 ~ 45
Benoit SR / 2005 / Risk factors for prolonged QTc among US adults: Third National Health and Nutrition Examination Survey / Eur J Cardiovasc Prev Rehabil : 368 ~
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