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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 456 - 461 (6page)
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Chemoresistance is a major barrier to successful cisplatinbased chemotherapy for epithelial ovarian cancer (EOC), and emerging evidences suggest that microRNAs (miRNAs) are involved in the resistance. In this study, it was indicated that miR-363 downregulation was significantly correlated with EOC carcinogenesis and cisplatin resistance. Moreover, miR-363 overexpression could resensitise cisplatin-resistant EOC cells to cisplatin treatment both in vitro and in vivo. In addition, data revealed that EMT inducer Snail was significantly upregulated in cisplatin-resistant EOC cell lines and EOC patients and was a functional target of miR-363 in EOC cells. Furthermore, snail overexpression could significantly attenuate miR-363-suppressed cisplatin resistance of EOC cells, suggesting that miR-363-regulated cisplatin resistance is mediated by snail-induced EMT in EOC cells. Taken together, findings suggest that miR-363 may be a biomarker for predicting responsiveness to cisplatin-based chemotherapy and a potential therapeutic target in EOC.
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참고문헌 (31)
참고문헌 신청
Chiu WT / 2015 / FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells / Oncotarget 6:2349~2365
Kuchenbaecker KB / 2015 / Identification of six new susceptibility loci for invasive epithelial ovarian cancer / Nat Genet 47:164~171
Raghavan R / 2016 / Drug discovery using clinical outcome-based Connectivity Mapping: application to ovarian cancer / BMC Genomics 17:811
Siddik ZH / 2003 / Cisplatin: mode of cytotoxic action and molecular basis of resistance / Oncogene 22:7265~7279
Zamble DB / 1995 / Cisplatin and DNA repair in cancer chemotherapy / Trends Biochem Sci 20:435~439
Kuchenbaecker KB / 2015 / Identification of six new susceptibility loci for invasive epithelial ovarian cancer / Nat Genet 47:164~171
Raghavan R / 2016 / Drug discovery using clinical outcome-based Connectivity Mapping: application to ovarian cancer / BMC Genomics 17:811
Siddik ZH / 2003 / Cisplatin: mode of cytotoxic action and molecular basis of resistance / Oncogene 22:7265~7279
Zamble DB / 1995 / Cisplatin and DNA repair in cancer chemotherapy / Trends Biochem Sci 20:435~439
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