지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 12 (12page)
이용수
초록· 키워드
오류제보하기
Interleukin (IL)-20, a proinflammatory cytokine of the IL-10 family, is involved in acute and chronic renal failure. The aim of this study was to elucidate the role of IL-20 during diabetic nephropathy development. We found that IL-20 and its receptor IL-20R1 were upregulated in the kidneys of mice and rats with STZ-induced diabetes. In vitro, IL-20 induced MMP-9, MCP-1, TGF-β1 and VEGF expression in podocytes. IL-20 was upregulated by hydrogen peroxide, high-dose glucose and TGF-β1. In addition, IL-20 induced apoptosis in podocytes by activating caspase-8. In STZ-induced early diabetic nephropathy, IL-20R1-deficient mice had lower blood glucose and serum BUN levels and a smaller glomerular area than did wild-type controls. Anti-IL-20 monoclonal antibody (7E) treatment reduced blood glucose and the glomerular area and improved renal functions in mice in the early stage of STZ-induced diabetic nephropathy. ELISA showed that the serum IL-20 level was higher in patients with diabetes mellitus than in healthy controls. The findings of this study suggest that IL-20 induces cell apoptosis of podocytes and plays a role in the pathogenesis of early diabetic nephropathy.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
[학술지(정기
Blumberg H / 2001 / Interleukin 20: discovery, receptor identification, and role in epidermal function / Cell 104 : 9 ~ 19
Bottinger EP / 2002 / TGF-beta signaling in renal disease / J Am Soc Nephrol 13 : 2600 ~ 2610
Brosius FC 3rd / 2008 / New insights into the mechanisms of fibrosis and sclerosis in diabetic nephropathy / Rev Endocr Metab Dis 9 : 245 ~ 254
Caligiuri G / 2006 / IL-20 and atherosclerosis : another brick in the wall / Arterioscler Thromb Vasc Biol 26 : 1929 ~ 1930
Blumberg H / 2001 / Interleukin 20: discovery, receptor identification, and role in epidermal function / Cell 104 : 9 ~ 19
Bottinger EP / 2002 / TGF-beta signaling in renal disease / J Am Soc Nephrol 13 : 2600 ~ 2610
Brosius FC 3rd / 2008 / New insights into the mechanisms of fibrosis and sclerosis in diabetic nephropathy / Rev Endocr Metab Dis 9 : 245 ~ 254
Caligiuri G / 2006 / IL-20 and atherosclerosis : another brick in the wall / Arterioscler Thromb Vasc Biol 26 : 1929 ~ 1930
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
IL-30† (IL-27A): a familiar stranger in immunity, inflammation, and cancer
Experimental and Molecular Medicine
2021 .05
-
IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation
Experimental and Molecular Medicine
2017 .01
-
A neutrophil elastase-generated mature form of IL-33 is a potent regulator of endothelial cell activation and proliferative retinopathy
Experimental and Molecular Medicine
2024 .08
-
Interleukin-32: Frenemy in cancer?
BMB Reports
2019 .01
-
Mesenchymal Stem Cell-Based Therapies against Podocyte Damage in Diabetic Nephropathy
조직공학과 재생의학
2017 .01
-
Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease
Experimental and Molecular Medicine
2024 .06
-
IL-17A exacerbates diabetic retinopathy by impairing Müller cell function via Act1 signaling
Experimental and Molecular Medicine
2016 .01
-
IL-33 and IL-33-derived DC-based tumor immunotherapy
Experimental and Molecular Medicine
2024 .06
-
Amelioration of STZ-Induced Proteinuric Rats by PI3K Inhibitor
한국생물공학회 학술대회
2015 .04
-
Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway
Experimental and Molecular Medicine
2020 .12
-
Harnessing IL-2 for immunotherapy against cancer and chronic infection: A historical perspective and emerging trends
Experimental and Molecular Medicine
2024 .09
-
IL-10 Deficiency Aggravates Renal Inflammation, Fibrosis and Functional Failure in High-Fat Dieted Obese Mice
조직공학과 재생의학
2021 .01
-
Ectopically Expressed Membrane-bound Form of IL-9 Exerts Immune-stimulatory Effect on CT26 Colon Carcinoma Cells
한국환경기술학회지
2017 .01
-
Effect of Interleukin-21 or Interleukin-27 for Peripheral Blood Mononuclear-derived Natural Killer Cell Culture
한국생물공학회 학술대회
2022 .09
-
Cancer immunotherapy with T-cell targeting cytokines: IL-2 and IL-7
BMB Reports
2021 .01
-
Interleukin-2/antibody complex expanding Foxp3＋ regulatory T cells exacerbates Th2-mediated allergic airway inflammation
BMB Reports
2019 .01
-
Molecular and Electrochemical Approaches for Studying IL-33 Binding Peptides Identified by Phage Display
한국생물공학회 학술대회
2021 .04
-
Silencing of long noncoding RNA PVT1 inhibits podocyte damage and apoptosis in diabetic nephropathy by upregulating FOXA1
Experimental and Molecular Medicine
2019 .01
-
Effect of TNF-α and IL-6 on Compact Bone-Derived Cells
조직공학과 재생의학
2021 .01
-
A novel anti-IL4Rα nanoparticle efficiently controls lung inflammation during asthma
Experimental and Molecular Medicine
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0