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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 98 - 102 (5page)
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Glutamate induced rapid phosphorylation of moe-sin, one of ERM family proteins involved in the ligation of membrane to actin cytoskeleton, in rat hipocampal cells (JBC, 277:16576-16584, 2002). However, the identity of glutamate receptor has not been explored. Here we show that a-amino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor is responsible for glutamate-induced RhoA activation and phosphorylation of moesin. Gluta-mate induced phosphorylation at Thr-58 of moe-sin was stil detectible upon chelation of Ca2+, sugesting involvement of AMPA receptor instead of N-methyl D-Aspartate (NMDA) receptor in this phosphorylation of moesin. AMPA but not NMDA- induced moesin phosphorylation was indepen-dent of Ca2+. Both AMPA and NMDA but not levels. However, the kinetics of phosphorylation varied greatly between AMPA and NMDA where AMPA treatment rapidly increased phosphomoe-sin, which reached a maximum at 10 min after treatment and returned to a basal level at 30 min. In contrast, NMDA-induced phosphorylation of moesin reached a maximum at 30 min after treatment and was remained at higher levels at 60 min. A possible involvement of RhoA and its downstream effector, Rho kinase in the AMPA receptor-trigered phosphorylation of moesin was also explored. The kinetics for the glutamate- in-duced membrane translocation of RhoA was simi-lar to that of moesin phosphorylation induced by AMPA. Moreover, Y-27632, a specific Rho kinase inhibitor, completely blocked AMPA-induced moesin phosphorylation but had no efect on NMDA-in-duced moesin phosphorylation. These results sug-gest that glutamate-induced phosphorylation of moesin may be mediated through the AMPA receptor/RhoA/Rho kinase pathway.
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참고문헌 (17)
참고문헌 신청
/ 1999 / CitronBinds to PSD-95 at glutamatergic synapses on inhibitory neuronsin the hippocampus : 96 ~ 108
/ 1999 / Rundown of somatodendritic N-methyl-D-aspartate receptor channels in rat hippocampal neurones evidence fora role of the small GTPase RhoA (reberg w) : 1060 ~ 3
/ 1999 / interactswith PSD-95/SAP-90 at glutamatergic synapeses in thethalamus uchi (s) : 109 ~ 18
/ 2000 / Rapiddendritic remodeling in the developing retina dependence onneurotransmission and reciprocal regulation by Rac and Rho : 5024 ~ 36
/ 2001 / Proteomics of the nervous system : 259 ~ 66
/ 1999 / Rundown of somatodendritic N-methyl-D-aspartate receptor channels in rat hippocampal neurones evidence fora role of the small GTPase RhoA (reberg w) : 1060 ~ 3
/ 1999 / interactswith PSD-95/SAP-90 at glutamatergic synapeses in thethalamus uchi (s) : 109 ~ 18
/ 2000 / Rapiddendritic remodeling in the developing retina dependence onneurotransmission and reciprocal regulation by Rac and Rho : 5024 ~ 36
/ 2001 / Proteomics of the nervous system : 259 ~ 66
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