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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 57 - 65 (9page)
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Clinical studies have shown that tumor hypoxia is
associated with invasive growth and metastasis
and may be an important prognostic factor adversely
influencing survival in patients with tumors.
To investigate the mechanisms involved in
hypoxia-induced invasive growth and metastasis,
hypoxia-mediated urokinase plasmalogen activator
receptor (uPAR) expression, cellular invasiveness,
and mitogen activated protein kinase (MAPK) activation
were measured in a prostate cancer cell
line, PC3MLN4. The levels of uPAR expression and
cellular invasiveness were increased in hypoxic
cells. Hypoxia-induced cellular invasiveness was
blocked by an anti-uPAR monoclonal antibody.
Phosphorylations of ERK and p38 kinases were
also more extensive in hypoxic cells than in normoxic
cells. Hypoxia-induced uPAR up-regulation
was inhibited by pre-treatments with a specific
inhibitor of MEK, PD98059 and a specific inhibitor
of p38 MAP kinase, SB203580. Cell growth also
increased in hypoxic cells. From these results,
hypoxia increased tumor cell invasion by up-regulating
uPAR expression, which might be mediated
through ERK and p38 kinase signaling
pathways in PC3MLN4 prostate cancer cell line.
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참고문헌 (26)
참고문헌 신청
/ / Content andcharacterization of plasminogen activators in human lungtumors and normal lung tissue : 841 ~ 8
/ / Establishmentand characterizaton of first trimester human trophoblastcells with extended lifespan : 206 ~ 12
/ / Examination of the effects of epidermal growthfactor on the production of urokinase and expression of theplasminogen activator receptor in a human colon cancer cellline :
/ / In vivo invasion of modified chorioallantoicmembrane by tumor cells the role of cell surface boundurokinase : 2437 ~ 45
/ / In vivo paracrineinteraction between urokinase and its receptor : 1107 ~ 12
/ / Establishmentand characterizaton of first trimester human trophoblastcells with extended lifespan : 206 ~ 12
/ / Examination of the effects of epidermal growthfactor on the production of urokinase and expression of theplasminogen activator receptor in a human colon cancer cellline :
/ / In vivo invasion of modified chorioallantoicmembrane by tumor cells the role of cell surface boundurokinase : 2437 ~ 45
/ / In vivo paracrineinteraction between urokinase and its receptor : 1107 ~ 12
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