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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 353 - 364 (12page)
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초록· 키워드
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Hypoxia, a common consequence of solid tumor growth in breast cancer or other cancers, serves to propagate a cascade of molecular pathways which include angiogenesis, glycolysis, and various cell- cycle control proteins. As we have shown previously, hypoxia activates STAT5 (signal transducer and activator of transcription 5) and increases its binding activity to the GAS element in mammary epithelial cells. In this study we attempted to elucidate the mechanism by which cyclin D1 is regulated by the STAT5 protein under hypoxic conditions. Our data demonstrate that hypoxia (2% O2) or desferrioxamine (DFO) induces tyrosine and serine phosphorylation of STAT5 in human breast cancer cells (MCF-7) and mammary epithelial cells (HC11). Imunoprecipi-tation and subsequent Western analysis showed that activation of STAT5a or STAT5b under hypoxic conditions. Using a transfected COS-7 cell model system, we demonstrate that the activity of a cyclin D1 promoter-luciferase construct increased under hypoxic conditions or DFO treatment. The activity of the STAT5b/cyclin D1 promoter increased signifi-cantly by 12 h of hypoxia, whereas the activity of the STAT5a/cyclin D1 promoter was unaffected under hypoxic conditions. These increases in promoter activity are predominantly mediated by the Jak2/ STAT5b signaling pathway. We have shown by EMSA that hypoxia induces STAT5 to bind to the cyclin D1 promoter (GAS-1) in MCF-7 and HC11 cells. These data suggest that STAT5b may mediate the trans-criptional activation of cyclin D1 after hypoxic stimulation.
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참고문헌 (33)
참고문헌 신청
/ / Cyclin D1 protein expression and function in human breastcancer : 353 ~ 61
/ / CyclinD1 induction in breast cancer cells shortens G1 and issufficient for cells arrested in G1 to complete the cell cycle : 8022 ~ 6
/ / Iron deprivation-induced apoptosis in HL-60 cells : 139 ~ 42
/ 1995 / Cytokine receptor signaling.
/ 1995 / Ras transformation results in an elevated level of cyclin D1and acceleration of G1 progression in NIH 3T3 cells
/ / CyclinD1 induction in breast cancer cells shortens G1 and issufficient for cells arrested in G1 to complete the cell cycle : 8022 ~ 6
/ / Iron deprivation-induced apoptosis in HL-60 cells : 139 ~ 42
/ 1995 / Cytokine receptor signaling.
/ 1995 / Ras transformation results in an elevated level of cyclin D1and acceleration of G1 progression in NIH 3T3 cells
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Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells
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JAK Kinases and STAT Proteins in IL-12 Receptor Signaling
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JAK Kinases and STAT Proteins IN IL-12 Receptor Signaling
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Modulation of the caveolin-3 localization to caveolae and STAT3 to mitochondria by catecholamine-induced cardiac hypertrophy in H9c2 cardiomyoblasts
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STAT6 Gene Polymorphisms in Allergic Rhinitis
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Curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by STAT-3 signaling
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LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression
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Activated Rac1 regulates the degradation of IκBα and the nuclear translocation of STAT3–NFκB complexes in starved cancer cells
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Jak-STAT Pathway Enhances KSHV Replication in Endothelial Cells
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Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression
Experimental and Molecular Medicine
2006 .01
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마그놀롤의 HDF세포에서 Nrf2-SOCS3-Jak2-STAT3에 의한 UVB 유래 염증데미지 조절
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Suppression of Antimicrobial Defense and Stabilization of STAT3 by IRAK-M Expression in Tumor Cells Promotes Colorectal Carcinogenesis
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .09
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Calpain protease에 의한 cyclin D3의 post-translation조절
생명과학회지
2015 .01
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Involvement of MAPK pathway in hypoxia-induced up-regulation of urokinase plasminogen activator receptor in a human prostatic cancer cell line, PC3MLN4
Experimental and Molecular Medicine
2004 .01
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Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells
Experimental and Molecular Medicine
2015 .01
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형질전환 초파리를 이용한 Drosophila raf 유전자 발현조절영역에 존재하는 STAT결합부위의 역할에 관한 연구 ( Analysis of the Role of STAT Binding Site in the Drosophila raf Promoter Region Using Transgenic Flies )
생명과학회지
1999 .02
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Hypoxia induces Wee1 expression and attenuates hydrogen peroxide-induced endothelial damage in MS1 cells
Experimental and Molecular Medicine
2011 .01
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Expression of Cyclin D3 Transcripts in the Postmeiotic Male Germ Cells of the Mouse
Korean journal of biological sciences
1998 .01
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