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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 217 - 225 (9page)
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초록· 키워드
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Phagocytes such as neutrophils play a vital role in host
defense against microbial pathogens. The anti-microbial
function of neutrophils is based on the production
of superoxide anion (O2 -), which generates other microbicidal
reactive oxygen species (ROS) and release of
antimicrobial peptides and proteins. The enzyme responsible
for O2 - production is called the NADPH oxidase
or respiratory burst oxidase. This multicomponent
enzyme system is composed of two transmembrane
proteins (p22phox and gp91phox, also
called NOX2, which together form the cytochrome b558)
and four cytosolic proteins (p47phox, p67phox,
p40phox and a GTPase Rac1 or Rac2), which assemble
at membrane sites upon cell activation. NADPH oxidase
activation in phagocytes can be induced by a
large number of soluble and particulate agents. This
process is dependent on the phosphorylation of the cytosolic
protein p47phox. p47phox is a 390 amino acids
protein with several functional domains: one phox homology
(PX) domain, two src homology 3 (SH3) domains,
an auto-inhibitory region (AIR), a proline rich
domain (PRR) and has several phosphorylated sites located
between Ser303 and Ser379. In this review, we
will describe the structure of p47phox, its phosphorylation
and discuss how these events regulate NADPH
oxidase activation.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Ago T / 1999 / Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with asparta
Ago T / 2003 / Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation / Proc Natl Aca
Albanis E / 2001 / Hepatic fibrosis. Pathogenesis and principles of therapy / Clin Liver Dis 5 : 315 ~ 334
Babior BM / 1984 / Oxidants from phagocytes: agents of defense and destruction / Blood 64 : 959 ~ 966
Babior BM / 1999 / NADPH Oxidase: an update / Blood 93 : 1464 ~ 1476
Ago T / 2003 / Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation / Proc Natl Aca
Albanis E / 2001 / Hepatic fibrosis. Pathogenesis and principles of therapy / Clin Liver Dis 5 : 315 ~ 334
Babior BM / 1984 / Oxidants from phagocytes: agents of defense and destruction / Blood 64 : 959 ~ 966
Babior BM / 1999 / NADPH Oxidase: an update / Blood 93 : 1464 ~ 1476
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