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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 243 - 252 (10page)
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Oxidative stress is critical for causing cardiac injuries during ischemia-reperfusion (IR), yet the molecular mechanism for this remains unclear. In the present study, we observe that hypoxia and reoxygenation, a component of ischemia, effectively induces apoptosis in the cardiac myocytes from neonatal rats and it concomitantly leads to induction of GADD153, an apoptosis- related gene. Furthermore, IR injury of rat heart showed a GADD153 overexpression in the ischemic area where the TUNEL reaction was positive. A downregulation of cardiac ankyrin repeat protein (CARP) was also observed in this ischemic area. Promoter deletion and reporter analysis revealed that hypoxia transcriptionally activates a GADD153 promoter through the AP-1 element in neonatal cardiomyocytes. Ectopic overexpression of GADD153 resulted in the downregulation of CARP expression. Accordingly, the induction of GADD153 mRNA were followed by the CARP down-regulation in an in vivo rat coronary ischemia/reperfusion injury model. These results suggest that GADD153 over-expression and the resulting downregulation of CARP may have causative roles in apoptotic cell death during cardiac IR injury.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Adachi S / 2001 / Cyclin A/cdk2 activation is involved in hypoxia-induced apoptosis in cardiomyocytes / Circ Res 88 : 408 ~ 414
Aihara Y / 2000 / Cardiac ankyrin repeat protein is a novel marker of cardiac hypertrophy: role of M-CAT element within the promoter / Hypertension 36 : 48 ~ 53
Barone MV / 1994 / CHOP(GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest / Genes Dev 8 : 453 ~ 464
Bartlett JD / 1992 / Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancerbinding protein (C/EBP)-related gene, gadd153. Ca
Cao Z / 1991 / Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells / Genes Dev 5 : 1538 ~ 1552
Aihara Y / 2000 / Cardiac ankyrin repeat protein is a novel marker of cardiac hypertrophy: role of M-CAT element within the promoter / Hypertension 36 : 48 ~ 53
Barone MV / 1994 / CHOP(GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest / Genes Dev 8 : 453 ~ 464
Bartlett JD / 1992 / Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancerbinding protein (C/EBP)-related gene, gadd153. Ca
Cao Z / 1991 / Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells / Genes Dev 5 : 1538 ~ 1552
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