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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 653 - 662 (10page)
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초록· 키워드
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Recent studies have shown that side population (SP) cells, isolated from adult myocardium, represent a distinct cardiac progenitor cell population that exhibits functional cardiomyogenic differentiation. However, information on the intrinsic characteristics and endothelial potential, of cardiac SP cells, is limited. The present study was designed to investigate whether cardiac SP cells exhibit endothelial differentiation potential.
The cardiac SP cells more highly expressed the early cardiac transcription factors as well as endothelial cell markers compared to the bone marrow-SP cells. After treatment with VEGF, for 28 days, cardiac SP cells were able to differentiate into endothelial cells expressing von Willebrand factor as determined by immunocytochemistry.
Furthermore, expression of endothelial cell markers increased several-fold in VEGF-treated cardiac SP cells compared to the control group when assessed by real-time PCR. We also confirmed that cardiac SP cells provided a significantly augmented ratio of ischemic/normal blood flow, in the cardiac SP cell-transplanted group compared with saline-treated controls on postoperative days 7, 14, 21 and 28, in a murine model. These results show that cardiac SP cells may contribute to regeneration of injured heart tissues partly by transdifferentiation into angiogenic lineages.
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참고문헌 (26)
참고문헌 신청
Asakura A / 2002 / Side population cells from diverse adult tissues are capable of in vitro hematipoietic differen-tiation 30 : 1339 ~ 1345
Askari AT / 2003 / Effect of stromal-cell-derived factor 1 on stem cell homing and tissue regeneration in ischaemic cardiomyopathy 362 : 697 ~ 703
Balsam LB / 2004 / Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium 428 : 668 ~ 673
Beltrami AP / 2001 / Evidence that human cardiac myocytes divide after myocardial infarction 344 : 1750 ~ 1757
Beltrami AP / 2003 / Nadal-Ginard B, Anversa P. Adult cardiac stem cells are multipotent and support myocardial regeneration 114 : 763 ~ 766
Askari AT / 2003 / Effect of stromal-cell-derived factor 1 on stem cell homing and tissue regeneration in ischaemic cardiomyopathy 362 : 697 ~ 703
Balsam LB / 2004 / Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium 428 : 668 ~ 673
Beltrami AP / 2001 / Evidence that human cardiac myocytes divide after myocardial infarction 344 : 1750 ~ 1757
Beltrami AP / 2003 / Nadal-Ginard B, Anversa P. Adult cardiac stem cells are multipotent and support myocardial regeneration 114 : 763 ~ 766
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