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- 자료유형
- 학술저널
- 저자정보
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- 2015.1
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The direct differentiation of hepatocytes from bone marrow cells remains controversial. Several mechanisms, including transdifferentiation and cell fusion, have been proposed for this phenomenon, although direct visualization of the process and the underlying mechanisms have not been reported. In this study, we established an efficient in vitro culture method for differentiation of functioning hepatocytes from murine lineage-negative bone marrow cells. These cells reduced liver damage and incorporated into hepatic parenchyma in two independent hepatic injury models. Our simple and efficient in vitro protocol for endodermal precursor cell survival and expansion enabled us to identify these cells as existing in Sca1+ subpopulations of lineage-negative bone marrow cells. The endodermal precursor cells followed a sequential developmental pathway that included endodermal cells and hepatocyte precursor cells, which indicates that lineage-negative bone marrow cells contain more diverse multipotent stem cells than considered previously. The presence of equivalent endodermal precursor populations in human bone marrow would facilitate the development of these cells into an effective treatment modality for chronic liver diseases.
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참고문헌 (26)
참고문헌 신청
Alqahtani SA / 2012 / Update in liver transplantation / Curr Opin Gastroenterol 28 : 230 ~ 238
Ben-David U / 2011 / The tumorigenicity of human embryonic and induced pluripotent stem cells / Nat Rev Cancer 11 : 268 ~ 277
Buck SB / 2008 / Detection of S-phase cell cycle progression using 5-ethynyl-2'-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2'-deoxyurid
Chen Y / 2007 / In vitro differentiation of mouse bone marrow stromal stem cells into hepatocytes induced by conditioned culture medium of hepatocytes / J Cell Biochem 102 :
Chistiakov DA / 2012 / Liver regenerative medicine : advances and challenges / Cells Tissues Organs 196 : 291 ~ 312
Ben-David U / 2011 / The tumorigenicity of human embryonic and induced pluripotent stem cells / Nat Rev Cancer 11 : 268 ~ 277
Buck SB / 2008 / Detection of S-phase cell cycle progression using 5-ethynyl-2'-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2'-deoxyurid
Chen Y / 2007 / In vitro differentiation of mouse bone marrow stromal stem cells into hepatocytes induced by conditioned culture medium of hepatocytes / J Cell Biochem 102 :
Chistiakov DA / 2012 / Liver regenerative medicine : advances and challenges / Cells Tissues Organs 196 : 291 ~ 312
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