지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 541 - 549 (9page)
이용수
초록· 키워드
오류제보하기
We have previously shown that seminal vesicle protein
IV (SV-IV) and its 1-70 N-terminal fragment have anti-inflammatory
activity and modulate anti-thrombin III (AT)
activity. Moreover, mass spectrometry analysis of purified
SV-IV has shown that the protein was found to be
highly heterogeneous and 14% of the total SV-IV molecules
are truncated forms, of particular interest the
1-16, 1-17, and 1-18 peptides. In this work we report experimental
data which demonstrate that the 1-16 peptide
(P1-16) possesses a marked effect on the AT activity
by preventing the formation of the thrombin-AT
complex. We found that the formation of thrombin-AT
complex is markedly decreased in the presence of
P1-16 used at equimolar concentration with thrombin
as evaluated with SDS-PAGE. We also monitored the conformational changes of thrombin in the presence
of different P1-16 concentrations, and calculated the Kd
of thrombin/P1-16 system by circular dichroism
technique. The probable interaction sites of P1-16 with
thrombin have been also evaluated by molecular
graphics and computational analyses. These results
have potential implications in the treatment of sterility
and thrombotic diseases.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Abrescia P / 1985 / Identification and preliminary characterization of a sperm-binding protein in normal human semen / J Reprod Fertil 73 : 71 ~ 7
Abrescia P / 1986 / Maturation in different translational systems of the protein RSV-IV secreted from the rat seminal vesicle epithelium / Bull Mol Bio Med 11 : 19 ~ 33
Camussi G / 1990 / An anti-inflammatory protein secreted from the rat seminal vesicle epithelium inhibits the synthesis of platelet-activating factor and the release of arach
D'Ambrosio E / 1993 / Cloning and expression of the rat genomic DNA sequence coding for the secreted form of the protein SV-IV / Bull Mol Biol Med 18 : 215 ~ 23
De Filippis V / 2005 / Effect of Na+ binding on the conformation, stability and molecular recognition properties of thrombin / Biochem J 390 : 485 ~ 92
Abrescia P / 1986 / Maturation in different translational systems of the protein RSV-IV secreted from the rat seminal vesicle epithelium / Bull Mol Bio Med 11 : 19 ~ 33
Camussi G / 1990 / An anti-inflammatory protein secreted from the rat seminal vesicle epithelium inhibits the synthesis of platelet-activating factor and the release of arach
D'Ambrosio E / 1993 / Cloning and expression of the rat genomic DNA sequence coding for the secreted form of the protein SV-IV / Bull Mol Biol Med 18 : 215 ~ 23
De Filippis V / 2005 / Effect of Na+ binding on the conformation, stability and molecular recognition properties of thrombin / Biochem J 390 : 485 ~ 92
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Screening of New Thrombin Inhibitor on Blood Sucking Animal
한국동물학회 학술대회
1995 .01
-
Bactericidal Activity of Thrombin-induced Platelet Microbicidal Protein Against Streptococcus rattus BHT
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2001 .12
-
Hexane and Chloroform Fractions of Laetiporus sulphrueus var. miniatus Inhibit Thrombin-treated Matrix Metalloproteinase-2/9 Expression in Human Oral Squamous Carcinoma YD-10B Cells
한국균학회지
2017 .01
-
Direct Thrombin Inhibition by 2α-hydroxy-oleanolic acid Isolated from Syzygium aromaticum
한국생명과학회 심포지움
2005 .09
-
식용 및 약용 산채류로부터 트롬빈 저해물질의 탐색
생명과학회지
2004 .06
-
야생버섯 메탄올추출물의 생리활성 검색
한국균학회지
2012 .01
-
자생곤충으로부터 트롬빈 저해물질의 탐색 및 DPPH radical 소거활성
생명과학회지
2008 .03
-
YD-10B 인간구강암세포주에서 생강 유기용매 분획물의 항산화, 트롬빈억제 및 thrombin에 의해 처리된 암 침윤 및 전이 억제 효과
생명과학회지
2016 .11
-
Identification of a Neolignan Glycoside from the Pine Tree, Pinus densiflora Showed Antithrombotic Activity
생명과학회지
2014 .08
-
노루궁뎅이버섯 물 추출물 및 유기용매 분획물의 생리활성 효과
한국균학회지
2012 .01
-
장수상황버섯 균사체를 이용한 한약재의 고체발효 및 메탄올 추출물의 트롬빈 저해 활성과 항산화 활성
한국미생물·생명공학회지
2008 .01
-
산사자 추출물의 트롬빈 저해활성
생명과학회지
2007 .04
-
Confidence Interval Estimation Using SV in LS-SVM
한국데이터정보과학회지
2003 .09
-
야생 꽃송이버섯 추출물의 생리활성
한국균학회지
2015 .01
-
Construction of an expression vector with SV40 DNA in a mammalian cell
미생물학회지
1987 .09
-
Aged Garlic Extract and Its Components Inhibit Platelet Aggregation in Rat
생명과학회지
2011 .10
-
Tyrosine nitration site specificity identified by LC/MS innitrite-modified collagen type IV
Experimental and Molecular Medicine
2007 .01
-
The Novel Assay Method for Thrombin by Weighing Fibrin Clot
생명과학회지
2004 .06
-
33종 생약재의 in-vitro 항혈전 활성 평가
생명과학회지
2010 .06
-
Theoretical Peptide Mass Distribution in the Non-Redundant Protein Database of the NCBI
Genomics & informatics
2006 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0