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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 80 - 84 (5page)
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초록· 키워드
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The in vitro antibacterial activities of anti-acne agents prepared from the extracts of natural sources were investigated against several bacteria
including antibiotic-susceptible and -resistant Propionibacterium acnes. SD-1 and SD-2 were prepared with different formulations and they showed strong antibacterial activities. The anti-acne agents completely inhibited
the growth of the tested strains at the concentration of 0.5%. There was no difference in antibacterial activity between antibiotic-susceptible and -resistant P. acnes. The inhibitory activities of two agents showed
time-dependent manner. In S. aureus, time-kill curve demonstrated 2.8- and 3.4-log10-unit killing after 8 h with SD-1 and SD-2, respectively. In P. acnes, time-killing curve demonstrated 5.1- and 6.1-log10-unit killing after 24 h with SD-1 and SD-2, respectively. SD-2 showed stronger antimicrobial activity than SD-1. From these results, we expect that SD-1 and SD-2 have strong antibacterial activities and have advantages for treating acne.
목차
등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Baker, D. D / 2007 / The value of natural products to future pharmaceutical discovery / Nat. Prod. Rep 24 : 1225 ~ 1244
Burton, J. L / 1971 / The relationship between seborrhea and acne vulgaris / Br. J. Dermatol 84 : 600 ~ 604
Cunliffe, W. J / 2004 / Comedone formation: etiology, clinical presentation, and treatment / Clin. Dermatol 22 : 367 ~ 374
Lam, K. S / 2007 / New aspects of natural products in drug discovery / Trends Microbiol 15 : 279 ~ 289
Lim, Y. S / 1995 / A study on the MIC of antibiotics for Propionibacterium acnes in patients with acne / Kor. J. Dermatol 33 : 437 ~ 444
Burton, J. L / 1971 / The relationship between seborrhea and acne vulgaris / Br. J. Dermatol 84 : 600 ~ 604
Cunliffe, W. J / 2004 / Comedone formation: etiology, clinical presentation, and treatment / Clin. Dermatol 22 : 367 ~ 374
Lam, K. S / 2007 / New aspects of natural products in drug discovery / Trends Microbiol 15 : 279 ~ 289
Lim, Y. S / 1995 / A study on the MIC of antibiotics for Propionibacterium acnes in patients with acne / Kor. J. Dermatol 33 : 437 ~ 444
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